Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the novel coronavirus disease 2019 (COVID-19), which is characterized by a diverse clinical picture. Children are often asymptomatic or experience mild symptoms and have a milder disease course compared to adults...

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Autores principales:	Julie Niemann Holm-Jacobsen, Julia Helena Vonasek, Søren Hagstrøm, Mette Line Donneborg, Suzette Sørensen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 SARS-CoV-2 Neonate Rectal shedding Case report Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/895b977223fc4e9e947d831a82c67c5d
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spelling	oai:doaj.org-article:895b977223fc4e9e947d831a82c67c5d2021-11-14T12:33:26ZProlonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report10.1186/s12887-021-02976-71471-2431https://doaj.org/article/895b977223fc4e9e947d831a82c67c5d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02976-7https://doaj.org/toc/1471-2431Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the novel coronavirus disease 2019 (COVID-19), which is characterized by a diverse clinical picture. Children are often asymptomatic or experience mild symptoms and have a milder disease course compared to adults. Rectal shedding of SARS-CoV-2 has been observed in both adults and children, suggesting the fecal-oral route as a potential route of transmission. However, only a few studies have investigated this in neonates. We present a neonate with a mild disease course and prolonged rectal SARS-CoV-2 shedding. Case presentation A 22-day old neonate was admitted to the hospital with tachycardia and a family history of COVID-19. The boy later tested positive for COVID-19. His heart rate normalized overnight without intervention , but a grade 1/6 heart murmur on the left side of the sternum was found. After excluding signs of heart failure, the boy was discharged in a habitual state after three days of admission. During his admission, he was enrolled in a clinical study examining the rectal shedding of SARS-CoV-2. He was positive for SARS-CoV-2 in his pharyngeal swabs for 11 days after initial diagnosis and remained positive in his rectal swabs for 45 days. Thereby, the boy remained positive in his rectal swabs for 29 days after his first negative pharyngeal swab. Conclusions The presented case shows that neonates with a mild disease course can shed SARS-CoV-2 in the intestines for 45 days. In the current case, it was not possible to determine if fecal-oral transfer to the family occurred, and more research is needed to establish the potential risk of the fecal-oral transmission route.Julie Niemann Holm-JacobsenJulia Helena VonasekSøren HagstrømMette Line DonneborgSuzette SørensenBMCarticleCOVID-19SARS-CoV-2NeonateRectal sheddingCase reportPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 Neonate Rectal shedding Case report Pediatrics RJ1-570
spellingShingle	COVID-19 SARS-CoV-2 Neonate Rectal shedding Case report Pediatrics RJ1-570 Julie Niemann Holm-Jacobsen Julia Helena Vonasek Søren Hagstrøm Mette Line Donneborg Suzette Sørensen Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report
description	Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the novel coronavirus disease 2019 (COVID-19), which is characterized by a diverse clinical picture. Children are often asymptomatic or experience mild symptoms and have a milder disease course compared to adults. Rectal shedding of SARS-CoV-2 has been observed in both adults and children, suggesting the fecal-oral route as a potential route of transmission. However, only a few studies have investigated this in neonates. We present a neonate with a mild disease course and prolonged rectal SARS-CoV-2 shedding. Case presentation A 22-day old neonate was admitted to the hospital with tachycardia and a family history of COVID-19. The boy later tested positive for COVID-19. His heart rate normalized overnight without intervention , but a grade 1/6 heart murmur on the left side of the sternum was found. After excluding signs of heart failure, the boy was discharged in a habitual state after three days of admission. During his admission, he was enrolled in a clinical study examining the rectal shedding of SARS-CoV-2. He was positive for SARS-CoV-2 in his pharyngeal swabs for 11 days after initial diagnosis and remained positive in his rectal swabs for 45 days. Thereby, the boy remained positive in his rectal swabs for 29 days after his first negative pharyngeal swab. Conclusions The presented case shows that neonates with a mild disease course can shed SARS-CoV-2 in the intestines for 45 days. In the current case, it was not possible to determine if fecal-oral transfer to the family occurred, and more research is needed to establish the potential risk of the fecal-oral transmission route.
format	article
author	Julie Niemann Holm-Jacobsen Julia Helena Vonasek Søren Hagstrøm Mette Line Donneborg Suzette Sørensen
author_facet	Julie Niemann Holm-Jacobsen Julia Helena Vonasek Søren Hagstrøm Mette Line Donneborg Suzette Sørensen
author_sort	Julie Niemann Holm-Jacobsen
title	Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report
title_short	Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report
title_full	Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report
title_fullStr	Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report
title_full_unstemmed	Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report
title_sort	prolonged rectal shedding of sars-cov-2 in a 22-day-old-neonate: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/895b977223fc4e9e947d831a82c67c5d
work_keys_str_mv	AT julieniemannholmjacobsen prolongedrectalsheddingofsarscov2ina22dayoldneonateacasereport AT juliahelenavonasek prolongedrectalsheddingofsarscov2ina22dayoldneonateacasereport AT sørenhagstrøm prolongedrectalsheddingofsarscov2ina22dayoldneonateacasereport AT mettelinedonneborg prolongedrectalsheddingofsarscov2ina22dayoldneonateacasereport AT suzettesørensen prolongedrectalsheddingofsarscov2ina22dayoldneonateacasereport
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Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate: a case report

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