Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

Mutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that the mutant protein gains a new function.

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Autores principales:	Samar Alsafadi, Alexandre Houy, Aude Battistella, Tatiana Popova, Michel Wassef, Emilie Henry, Franck Tirode, Angelos Constantinou, Sophie Piperno-Neumann, Sergio Roman-Roman, Martin Dutertre, Marc-Henri Stern
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/895eb1555d734fbe947b98b9284ba24c
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spelling	oai:doaj.org-article:895eb1555d734fbe947b98b9284ba24c2021-12-02T17:32:35ZCancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage10.1038/ncomms106152041-1723https://doaj.org/article/895eb1555d734fbe947b98b9284ba24c2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10615https://doaj.org/toc/2041-1723Mutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that the mutant protein gains a new function.Samar AlsafadiAlexandre HouyAude BattistellaTatiana PopovaMichel WassefEmilie HenryFranck TirodeAngelos ConstantinouSophie Piperno-NeumannSergio Roman-RomanMartin DutertreMarc-Henri SternNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samar Alsafadi Alexandre Houy Aude Battistella Tatiana Popova Michel Wassef Emilie Henry Franck Tirode Angelos Constantinou Sophie Piperno-Neumann Sergio Roman-Roman Martin Dutertre Marc-Henri Stern Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
description	Mutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that the mutant protein gains a new function.
format	article
author	Samar Alsafadi Alexandre Houy Aude Battistella Tatiana Popova Michel Wassef Emilie Henry Franck Tirode Angelos Constantinou Sophie Piperno-Neumann Sergio Roman-Roman Martin Dutertre Marc-Henri Stern
author_facet	Samar Alsafadi Alexandre Houy Aude Battistella Tatiana Popova Michel Wassef Emilie Henry Franck Tirode Angelos Constantinou Sophie Piperno-Neumann Sergio Roman-Roman Martin Dutertre Marc-Henri Stern
author_sort	Samar Alsafadi
title	Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
title_short	Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
title_full	Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
title_fullStr	Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
title_full_unstemmed	Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
title_sort	cancer-associated sf3b1 mutations affect alternative splicing by promoting alternative branchpoint usage
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/895eb1555d734fbe947b98b9284ba24c
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Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

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