Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure

Iwan Soebijantoro,1 Tjahjono D Gondhowiardjo,1 Marsetyawan Soesatyo2 1JEC Eye Hospitals and Clinics, Jakarta, Indonesia; 2Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, IndonesiaCorrespondence: Iwan SoebijantoroJEC Eye Hospitals and Clinics, Jalan Terusan Arjuna Utara Nomor 1, Jakarta Bar...

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Autores principales:	Soebijantoro I, Gondhowiardjo TD, Soesatyo M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	corneal endothelium primary angle closure glaucoma trabecular iris angle Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/89611a89021c41fdaf7a45b52263051d
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spelling	oai:doaj.org-article:89611a89021c41fdaf7a45b52263051d2021-12-02T17:02:14ZAssociation Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure1177-5483https://doaj.org/article/89611a89021c41fdaf7a45b52263051d2021-05-01T00:00:00Zhttps://www.dovepress.com/association-between-anterior-chamber-angle-and-corneal-endothelial-cel-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Iwan Soebijantoro,1 Tjahjono D Gondhowiardjo,1 Marsetyawan Soesatyo2 1JEC Eye Hospitals and Clinics, Jakarta, Indonesia; 2Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, IndonesiaCorrespondence: Iwan SoebijantoroJEC Eye Hospitals and Clinics, Jalan Terusan Arjuna Utara Nomor 1, Jakarta Barat, DKI, Jakarta, 11520, IndonesiaTel +62 813 1102 0020Email iwan@jec.co.idPurpose: To study the association between corneal endothelial cell density (ECD) and degree of anterior chamber angle (ACA) opening in eyes with chronic angle closure glaucoma.Methods: The study was conducted at JEC Eye Hospitals in Indonesia. Treatment-naïve patients aged ≥ 40 years with IOP > 21 mmHg and peripheral anterior chamber depth (ACD) grade 2 or less by Van Herick’s technique were recruited. Trabecular iris angle (TIA; degree) was measured using anterior segment optical coherence tomography (AS-OCT) and classified as: grade 1 ≤ 10°, grade 2 11– 20°, and grade 3 > 20°. Noncontact specular microscopy was performed, and the following corneal parameters were obtained:ECD (cells/mm2), coefficient of variation (CV; μm2/cell), percentage of hexagonal cells, and central corneal thickness (CCT; μm).Results: A total of 52 eyes from 52 subjects were recruited (16 grade 1 TIA, 24 grade 2 TIA, and 12 grade 3 TIA). Presenting IOP was not significantly different between groups. The median central corneal ECD was 2684.5 (1433– 2934), 2587.0 (1902– 3103), and 2441.0 (1659– 3005) cells/mm2 in grade 1, 2, and 3 TIA, respectively, with no significant differences across the groups (P = 0.67). The CV was lowest in grade 3 TIA (36.4 ± 7.2 μm2/cell), and highest in grade 1 TIA (38.3 ± 9.6 μm2/cell), but the differences were not significant (P = 0.74). Likewise, the percentage of hexagonality and CCT was not significantly different. TIA was not correlated with IOP but was modestly correlated with age.Conclusion: The corneal ECD and morphological characteristics such as CV and hexagonality were not significantly different across various TIA grading in chronic angle closure. This may reflect the lack of chronic and gradual IOP insult on corneal endothelial parameters as TIA did not show direct effect towards IOP.Keywords: corneal endothelium, primary angle closure glaucoma; PACG, trabecular iris angle; TIASoebijantoro IGondhowiardjo TDSoesatyo MDove Medical Pressarticlecorneal endotheliumprimary angle closure glaucomatrabecular iris angleOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1957-1964 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corneal endothelium primary angle closure glaucoma trabecular iris angle Ophthalmology RE1-994
spellingShingle	corneal endothelium primary angle closure glaucoma trabecular iris angle Ophthalmology RE1-994 Soebijantoro I Gondhowiardjo TD Soesatyo M Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure
description	Iwan Soebijantoro,1 Tjahjono D Gondhowiardjo,1 Marsetyawan Soesatyo2 1JEC Eye Hospitals and Clinics, Jakarta, Indonesia; 2Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, IndonesiaCorrespondence: Iwan SoebijantoroJEC Eye Hospitals and Clinics, Jalan Terusan Arjuna Utara Nomor 1, Jakarta Barat, DKI, Jakarta, 11520, IndonesiaTel +62 813 1102 0020Email iwan@jec.co.idPurpose: To study the association between corneal endothelial cell density (ECD) and degree of anterior chamber angle (ACA) opening in eyes with chronic angle closure glaucoma.Methods: The study was conducted at JEC Eye Hospitals in Indonesia. Treatment-naïve patients aged ≥ 40 years with IOP > 21 mmHg and peripheral anterior chamber depth (ACD) grade 2 or less by Van Herick’s technique were recruited. Trabecular iris angle (TIA; degree) was measured using anterior segment optical coherence tomography (AS-OCT) and classified as: grade 1 ≤ 10°, grade 2 11– 20°, and grade 3 > 20°. Noncontact specular microscopy was performed, and the following corneal parameters were obtained:ECD (cells/mm2), coefficient of variation (CV; μm2/cell), percentage of hexagonal cells, and central corneal thickness (CCT; μm).Results: A total of 52 eyes from 52 subjects were recruited (16 grade 1 TIA, 24 grade 2 TIA, and 12 grade 3 TIA). Presenting IOP was not significantly different between groups. The median central corneal ECD was 2684.5 (1433– 2934), 2587.0 (1902– 3103), and 2441.0 (1659– 3005) cells/mm2 in grade 1, 2, and 3 TIA, respectively, with no significant differences across the groups (P = 0.67). The CV was lowest in grade 3 TIA (36.4 ± 7.2 μm2/cell), and highest in grade 1 TIA (38.3 ± 9.6 μm2/cell), but the differences were not significant (P = 0.74). Likewise, the percentage of hexagonality and CCT was not significantly different. TIA was not correlated with IOP but was modestly correlated with age.Conclusion: The corneal ECD and morphological characteristics such as CV and hexagonality were not significantly different across various TIA grading in chronic angle closure. This may reflect the lack of chronic and gradual IOP insult on corneal endothelial parameters as TIA did not show direct effect towards IOP.Keywords: corneal endothelium, primary angle closure glaucoma; PACG, trabecular iris angle; TIA
format	article
author	Soebijantoro I Gondhowiardjo TD Soesatyo M
author_facet	Soebijantoro I Gondhowiardjo TD Soesatyo M
author_sort	Soebijantoro I
title	Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure
title_short	Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure
title_full	Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure
title_fullStr	Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure
title_full_unstemmed	Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure
title_sort	association between anterior chamber angle and corneal endothelial cell density in chronic angle closure
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/89611a89021c41fdaf7a45b52263051d
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Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure

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