Suspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices

Abstract The miniaturization of synthesis, analysis and screening experiments is an important step towards more environmentally friendly chemistry, statistically significant biology and fast and cost-effective medicinal assays. The facile generation of arbitrary 3D channel structures in polymers is...

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Autores principales:	D. Helmer, A. Voigt, S. Wagner, N. Keller, K. Sachsenheimer, F. Kotz, T. M. Nargang, B. E. Rapp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/896383ad369841feb3271b8601bd5ab1
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spelling	oai:doaj.org-article:896383ad369841feb3271b8601bd5ab12021-12-02T15:05:33ZSuspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices10.1038/s41598-017-07630-w2045-2322https://doaj.org/article/896383ad369841feb3271b8601bd5ab12017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07630-whttps://doaj.org/toc/2045-2322Abstract The miniaturization of synthesis, analysis and screening experiments is an important step towards more environmentally friendly chemistry, statistically significant biology and fast and cost-effective medicinal assays. The facile generation of arbitrary 3D channel structures in polymers is pivotal to these techniques. Here we present a method for printing microchannels directly into viscous curable polymer matrices by injecting a surfactant into the uncured material via a steel capillary attached to a 3D printer. We demonstrate this technique using polydimethylsiloxane (PDMS) one of the most widely used polymers for the fabrication of, e. g. microfluidic chips. We show that this technique which we term Suspended Liquid Subtractive Lithography (SLSL) is well suited for printing actuators, T-junctions and complex three dimensional structures. The formation of truly arbitrary channels in 3D could revolutionize the fabrication of miniaturized chips and will find broad application in biology, chemistry and medicine.D. HelmerA. VoigtS. WagnerN. KellerK. SachsenheimerF. KotzT. M. NargangB. E. RappNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. Helmer A. Voigt S. Wagner N. Keller K. Sachsenheimer F. Kotz T. M. Nargang B. E. Rapp Suspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices
description	Abstract The miniaturization of synthesis, analysis and screening experiments is an important step towards more environmentally friendly chemistry, statistically significant biology and fast and cost-effective medicinal assays. The facile generation of arbitrary 3D channel structures in polymers is pivotal to these techniques. Here we present a method for printing microchannels directly into viscous curable polymer matrices by injecting a surfactant into the uncured material via a steel capillary attached to a 3D printer. We demonstrate this technique using polydimethylsiloxane (PDMS) one of the most widely used polymers for the fabrication of, e. g. microfluidic chips. We show that this technique which we term Suspended Liquid Subtractive Lithography (SLSL) is well suited for printing actuators, T-junctions and complex three dimensional structures. The formation of truly arbitrary channels in 3D could revolutionize the fabrication of miniaturized chips and will find broad application in biology, chemistry and medicine.
format	article
author	D. Helmer A. Voigt S. Wagner N. Keller K. Sachsenheimer F. Kotz T. M. Nargang B. E. Rapp
author_facet	D. Helmer A. Voigt S. Wagner N. Keller K. Sachsenheimer F. Kotz T. M. Nargang B. E. Rapp
author_sort	D. Helmer
title	Suspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices
title_short	Suspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices
title_full	Suspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices
title_fullStr	Suspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices
title_full_unstemmed	Suspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices
title_sort	suspended liquid subtractive lithography: one-step generation of 3d channel geometries in viscous curable polymer matrices
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/896383ad369841feb3271b8601bd5ab1
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Suspended Liquid Subtractive Lithography: One-step generation of 3D channel geometries in viscous curable polymer matrices

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