The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups

Yu Ran, Qiang Yi, Cong Li Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Cong LiDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, No. 1 YouYi Road, YuZhong...

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Autores principales:	Ran Y, Yi Q, Li C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	anti-mullerian hormone polycystic ovary syndrome hyperandrogenism polycystic ovary morphology Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/89638a89c9354d84bcccd58b7e503f82
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spelling	oai:doaj.org-article:89638a89c9354d84bcccd58b7e503f822021-12-02T16:34:29ZThe Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups1178-7007https://doaj.org/article/89638a89c9354d84bcccd58b7e503f822021-03-01T00:00:00Zhttps://www.dovepress.com/the-relationship-of-anti-mullerian-hormone-in-polycystic-ovary-syndrom-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yu Ran, Qiang Yi, Cong Li Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Cong LiDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, No. 1 YouYi Road, YuZhong District, Chongqing, People’s Republic of ChinaTel +8615334506105Fax +86023 89011080Email b05104@126.comPurpose: To explore the value of anti-Mullerian hormone (AMH) in patients with polycystic ovary syndrome (PCOS) with different phenotypes and ages, and to identify the relationship between hyperandrogenism (HA) and polycystic ovary morphology (PCOM), in a Chinese cohort.Methods: A total of 2262 women (1631 with PCOS and 631 controls) were enrolled. The serum AMH and total testosterone (TT) were analyzed, the AMH levels of each subgroup were compared, and the value of each phenotype and age group of patients with PCOS was evaluated.Results: The level of AMH in women with PCOS (mean±SD, 8.63± 4.73 ng/mL) was higher than that in controls (5.57± 3.31 ng/mL) (P< 0.01). The level of AMH in the PCOM subgroup (11.19± 6.4 ng/mL) was significantly higher than that in the HA subgroup (8.58± 4.74 ng/mL) (P< 0.01), and both were higher than that in controls (P< 0.01). AMH was higher in PCOS patients than in controls, but the same values were found in subgroups of PCOS patients under 30 years old.Conclusion: AMH changed in different subgroups of PCOS, which was the possible reason why AMH was not a diagnostic indicator. However, AMH could help to differentiate between clinical subgroups, as it was strongly related with PCOM but not with HA. AMH changed substantially with age, but was stable in PCOS patients under 30 years old.Keywords: anti-Mullerian hormone, polycystic ovary syndrome, hyperandrogenism, polycystic ovary morphologyRan YYi QLi CDove Medical Pressarticleanti-mullerian hormonepolycystic ovary syndromehyperandrogenismpolycystic ovary morphologySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1419-1424 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-mullerian hormone polycystic ovary syndrome hyperandrogenism polycystic ovary morphology Specialties of internal medicine RC581-951
spellingShingle	anti-mullerian hormone polycystic ovary syndrome hyperandrogenism polycystic ovary morphology Specialties of internal medicine RC581-951 Ran Y Yi Q Li C The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups
description	Yu Ran, Qiang Yi, Cong Li Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Cong LiDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, No. 1 YouYi Road, YuZhong District, Chongqing, People’s Republic of ChinaTel +8615334506105Fax +86023 89011080Email b05104@126.comPurpose: To explore the value of anti-Mullerian hormone (AMH) in patients with polycystic ovary syndrome (PCOS) with different phenotypes and ages, and to identify the relationship between hyperandrogenism (HA) and polycystic ovary morphology (PCOM), in a Chinese cohort.Methods: A total of 2262 women (1631 with PCOS and 631 controls) were enrolled. The serum AMH and total testosterone (TT) were analyzed, the AMH levels of each subgroup were compared, and the value of each phenotype and age group of patients with PCOS was evaluated.Results: The level of AMH in women with PCOS (mean±SD, 8.63± 4.73 ng/mL) was higher than that in controls (5.57± 3.31 ng/mL) (P< 0.01). The level of AMH in the PCOM subgroup (11.19± 6.4 ng/mL) was significantly higher than that in the HA subgroup (8.58± 4.74 ng/mL) (P< 0.01), and both were higher than that in controls (P< 0.01). AMH was higher in PCOS patients than in controls, but the same values were found in subgroups of PCOS patients under 30 years old.Conclusion: AMH changed in different subgroups of PCOS, which was the possible reason why AMH was not a diagnostic indicator. However, AMH could help to differentiate between clinical subgroups, as it was strongly related with PCOM but not with HA. AMH changed substantially with age, but was stable in PCOS patients under 30 years old.Keywords: anti-Mullerian hormone, polycystic ovary syndrome, hyperandrogenism, polycystic ovary morphology
format	article
author	Ran Y Yi Q Li C
author_facet	Ran Y Yi Q Li C
author_sort	Ran Y
title	The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups
title_short	The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups
title_full	The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups
title_fullStr	The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups
title_full_unstemmed	The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups
title_sort	relationship of anti-mullerian hormone in polycystic ovary syndrome patients with different subgroups
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/89638a89c9354d84bcccd58b7e503f82
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The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups

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