Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.

<h4>Purpose</h4>Childhood post-infectious bronchiolitis obliterans (BO) is an infrequent lung disease leading to narrowing and/or complete obliteration of small airways. Ventilation and perfusion (V/Q) scan can provide both regional and global pulmonary information. However, only few ret...

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Autores principales:	Bo-Qia Xie, Wei Wang, Wen-Qian Zhang, Xin-Hua Guo, Min-Fu Yang, Li Wang, Zuo-Xiang He, Yue-Qin Tian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/896ff93d9e0b481ca7a883bd23357b85
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spelling	oai:doaj.org-article:896ff93d9e0b481ca7a883bd23357b852021-11-18T08:18:20ZVentilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.1932-620310.1371/journal.pone.0098381https://doaj.org/article/896ff93d9e0b481ca7a883bd23357b852014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24852165/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>Childhood post-infectious bronchiolitis obliterans (BO) is an infrequent lung disease leading to narrowing and/or complete obliteration of small airways. Ventilation and perfusion (V/Q) scan can provide both regional and global pulmonary information. However, only few retrospective researches investigating post-infectious BO involved V/Q scan, the clinical value of this method is unknown. This preliminary prospective study was aimed to evaluate the correlation of V/Q scan with disease severity, pulmonary function test results, and prognosis in children with post-infectious BO.<h4>Methods</h4>Twenty-five post-infectious BO children (18 boys and 7 girls; mean age, 41 months) underwent V/Q scan and pulmonary function tests. Patients were followed after their inclusion. Ventilation index and perfusion index obtained from V/Q scan were used to measure pulmonary abnormalities. Spearman's rank correlation test of ventilation index and perfusion index on disease severity, lung function tests indices, and follow-up results were performed.<h4>Results</h4>The median follow-up period was 4.6 years (range, 2.2 to 5.0 years). Ventilation index and perfusion index were both correlated with disease severity (r = 0.72, p<0.01 and r = 0.73, p<0.01), but only ventilation index was related to pulmonary function tests results (all p<0.05). In addition, Spearman test yielded significant correlations between perfusion index and prognosis (r = 0.77, p<0.01), and ventilation index and prognosis (r = 0.63, p = 0.01).<h4>Conclusions</h4>For children with post-infectious BO, the present study preliminarily indicated that the degree of ventilation and perfusion abnormalities evaluated by V/Q scan may be used to assess disease severity, and may be predictive of patient's outcome.Bo-Qia XieWei WangWen-Qian ZhangXin-Hua GuoMin-Fu YangLi WangZuo-Xiang HeYue-Qin TianPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e98381 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo-Qia Xie Wei Wang Wen-Qian Zhang Xin-Hua Guo Min-Fu Yang Li Wang Zuo-Xiang He Yue-Qin Tian Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.
description	<h4>Purpose</h4>Childhood post-infectious bronchiolitis obliterans (BO) is an infrequent lung disease leading to narrowing and/or complete obliteration of small airways. Ventilation and perfusion (V/Q) scan can provide both regional and global pulmonary information. However, only few retrospective researches investigating post-infectious BO involved V/Q scan, the clinical value of this method is unknown. This preliminary prospective study was aimed to evaluate the correlation of V/Q scan with disease severity, pulmonary function test results, and prognosis in children with post-infectious BO.<h4>Methods</h4>Twenty-five post-infectious BO children (18 boys and 7 girls; mean age, 41 months) underwent V/Q scan and pulmonary function tests. Patients were followed after their inclusion. Ventilation index and perfusion index obtained from V/Q scan were used to measure pulmonary abnormalities. Spearman's rank correlation test of ventilation index and perfusion index on disease severity, lung function tests indices, and follow-up results were performed.<h4>Results</h4>The median follow-up period was 4.6 years (range, 2.2 to 5.0 years). Ventilation index and perfusion index were both correlated with disease severity (r = 0.72, p<0.01 and r = 0.73, p<0.01), but only ventilation index was related to pulmonary function tests results (all p<0.05). In addition, Spearman test yielded significant correlations between perfusion index and prognosis (r = 0.77, p<0.01), and ventilation index and prognosis (r = 0.63, p = 0.01).<h4>Conclusions</h4>For children with post-infectious BO, the present study preliminarily indicated that the degree of ventilation and perfusion abnormalities evaluated by V/Q scan may be used to assess disease severity, and may be predictive of patient's outcome.
format	article
author	Bo-Qia Xie Wei Wang Wen-Qian Zhang Xin-Hua Guo Min-Fu Yang Li Wang Zuo-Xiang He Yue-Qin Tian
author_facet	Bo-Qia Xie Wei Wang Wen-Qian Zhang Xin-Hua Guo Min-Fu Yang Li Wang Zuo-Xiang He Yue-Qin Tian
author_sort	Bo-Qia Xie
title	Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.
title_short	Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.
title_full	Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.
title_fullStr	Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.
title_full_unstemmed	Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.
title_sort	ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/896ff93d9e0b481ca7a883bd23357b85
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Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study.

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