Value of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies

Abstract To define an algorithm for differential diagnostics of parotid malignancies and Warthin tumors (WTs) based on dynamic contrast enhanced MRI (DCE-MRI). 55 patients with parotid tumors treated surgically were analyzed. Of which, 19 had parotid malignancy and 36 had WTs confirmed with postoper...

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Autores principales:	Bogusław Mikaszewski, Karolina Markiet, Aneta Smugała, Dominik Stodulski, Ewa Garsta, Jakub Piątkowski, Edyta Szurowska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89718925634e46cdbc862920cf1976d9
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spelling	oai:doaj.org-article:89718925634e46cdbc862920cf1976d92021-12-02T15:08:11ZValue of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies10.1038/s41598-021-95820-y2045-2322https://doaj.org/article/89718925634e46cdbc862920cf1976d92021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95820-yhttps://doaj.org/toc/2045-2322Abstract To define an algorithm for differential diagnostics of parotid malignancies and Warthin tumors (WTs) based on dynamic contrast enhanced MRI (DCE-MRI). 55 patients with parotid tumors treated surgically were analyzed. Of which, 19 had parotid malignancy and 36 had WTs confirmed with postoperative histopathological examination. Accuracy of DCE-MRI parameters (Tpeak and WR) was compared with the histopathological diagnosis. ROC analysis was performed to determine sensitivity and specificity of DCE-MRI with various Tpeak and WR cut-off values. WT showed significantly lower median Tpeak and higher median WR than malignant lesions. The cut-off values for Tpeak and WR providing maximum sensitivity (84.2%) and specificity (86.1%) for malignant tumors were Tpeak > 60 s and WR ≤ 30%. Different diagnostic algorithm, i.e., lower cut-off value for Tpeak (Tpeak = 60 s), increases sensitivity of DCE-MRI in differentiating parotid malignancies from WTs. However, WR > 30% seems to be a key diagnostic criterion for benign lesions. Precise and reliable preoperative diagnostics of parotid tumors aids in careful surgical planning, thereby assisting in achieving sufficient surgical resection margins and facial nerve preservation.Bogusław MikaszewskiKarolina MarkietAneta SmugałaDominik StodulskiEwa GarstaJakub PiątkowskiEdyta SzurowskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bogusław Mikaszewski Karolina Markiet Aneta Smugała Dominik Stodulski Ewa Garsta Jakub Piątkowski Edyta Szurowska Value of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies
description	Abstract To define an algorithm for differential diagnostics of parotid malignancies and Warthin tumors (WTs) based on dynamic contrast enhanced MRI (DCE-MRI). 55 patients with parotid tumors treated surgically were analyzed. Of which, 19 had parotid malignancy and 36 had WTs confirmed with postoperative histopathological examination. Accuracy of DCE-MRI parameters (Tpeak and WR) was compared with the histopathological diagnosis. ROC analysis was performed to determine sensitivity and specificity of DCE-MRI with various Tpeak and WR cut-off values. WT showed significantly lower median Tpeak and higher median WR than malignant lesions. The cut-off values for Tpeak and WR providing maximum sensitivity (84.2%) and specificity (86.1%) for malignant tumors were Tpeak > 60 s and WR ≤ 30%. Different diagnostic algorithm, i.e., lower cut-off value for Tpeak (Tpeak = 60 s), increases sensitivity of DCE-MRI in differentiating parotid malignancies from WTs. However, WR > 30% seems to be a key diagnostic criterion for benign lesions. Precise and reliable preoperative diagnostics of parotid tumors aids in careful surgical planning, thereby assisting in achieving sufficient surgical resection margins and facial nerve preservation.
format	article
author	Bogusław Mikaszewski Karolina Markiet Aneta Smugała Dominik Stodulski Ewa Garsta Jakub Piątkowski Edyta Szurowska
author_facet	Bogusław Mikaszewski Karolina Markiet Aneta Smugała Dominik Stodulski Ewa Garsta Jakub Piątkowski Edyta Szurowska
author_sort	Bogusław Mikaszewski
title	Value of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies
title_short	Value of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies
title_full	Value of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies
title_fullStr	Value of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies
title_full_unstemmed	Value of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies
title_sort	value of dynamic contrast enhanced mri in differential diagnostics of warthin tumors and parotid malignancies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/89718925634e46cdbc862920cf1976d9
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Value of dynamic contrast enhanced MRI in differential diagnostics of Warthin tumors and parotid malignancies

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