Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study

Abstract There is little evidence on the applicability of deep learning (DL) in the segmentation of acute ischemic lesions on diffusion-weighted imaging (DWI) between magnetic resonance imaging (MRI) scanners of different manufacturers. We retrospectively included DWI data of patients with acute isc...

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Autores principales:	Deniz Alis, Mert Yergin, Ceren Alis, Cagdas Topel, Ozan Asmakutlu, Omer Bagcilar, Yeseren Deniz Senli, Ahmet Ustundag, Vefa Salt, Sebahat Nacar Dogan, Murat Velioglu, Hakan Hatem Selcuk, Batuhan Kara, Ilkay Oksuz, Osman Kizilkilic, Ercan Karaarslan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/897683b2837b4094b80466289ed7a30d
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spelling	oai:doaj.org-article:897683b2837b4094b80466289ed7a30d2021-12-02T17:40:49ZInter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study10.1038/s41598-021-91467-x2045-2322https://doaj.org/article/897683b2837b4094b80466289ed7a30d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91467-xhttps://doaj.org/toc/2045-2322Abstract There is little evidence on the applicability of deep learning (DL) in the segmentation of acute ischemic lesions on diffusion-weighted imaging (DWI) between magnetic resonance imaging (MRI) scanners of different manufacturers. We retrospectively included DWI data of patients with acute ischemic lesions from six centers. Dataset A (n = 2986) and B (n = 3951) included data from Siemens and GE MRI scanners, respectively. The datasets were split into the training (80%), validation (10%), and internal test (10%) sets, and six neuroradiologists created ground-truth masks. Models A and B were the proposed neural networks trained on datasets A and B. The models subsequently fine-tuned across the datasets using their validation data. Another radiologist performed the segmentation on the test sets for comparisons. The median Dice scores of models A and B were 0.858 and 0.857 for the internal tests, which were non-inferior to the radiologist’s performance, but demonstrated lower performance than the radiologist on the external tests. Fine-tuned models A and B achieved median Dice scores of 0.832 and 0.846, which were non-inferior to the radiologist's performance on the external tests. The present work shows that the inter-vendor operability of deep learning for the segmentation of ischemic lesions on DWI might be enhanced via transfer learning; thereby, their clinical applicability and generalizability could be improved.Deniz AlisMert YerginCeren AlisCagdas TopelOzan AsmakutluOmer BagcilarYeseren Deniz SenliAhmet UstundagVefa SaltSebahat Nacar DoganMurat VeliogluHakan Hatem SelcukBatuhan KaraIlkay OksuzOsman KizilkilicErcan KaraarslanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deniz Alis Mert Yergin Ceren Alis Cagdas Topel Ozan Asmakutlu Omer Bagcilar Yeseren Deniz Senli Ahmet Ustundag Vefa Salt Sebahat Nacar Dogan Murat Velioglu Hakan Hatem Selcuk Batuhan Kara Ilkay Oksuz Osman Kizilkilic Ercan Karaarslan Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study
description	Abstract There is little evidence on the applicability of deep learning (DL) in the segmentation of acute ischemic lesions on diffusion-weighted imaging (DWI) between magnetic resonance imaging (MRI) scanners of different manufacturers. We retrospectively included DWI data of patients with acute ischemic lesions from six centers. Dataset A (n = 2986) and B (n = 3951) included data from Siemens and GE MRI scanners, respectively. The datasets were split into the training (80%), validation (10%), and internal test (10%) sets, and six neuroradiologists created ground-truth masks. Models A and B were the proposed neural networks trained on datasets A and B. The models subsequently fine-tuned across the datasets using their validation data. Another radiologist performed the segmentation on the test sets for comparisons. The median Dice scores of models A and B were 0.858 and 0.857 for the internal tests, which were non-inferior to the radiologist’s performance, but demonstrated lower performance than the radiologist on the external tests. Fine-tuned models A and B achieved median Dice scores of 0.832 and 0.846, which were non-inferior to the radiologist's performance on the external tests. The present work shows that the inter-vendor operability of deep learning for the segmentation of ischemic lesions on DWI might be enhanced via transfer learning; thereby, their clinical applicability and generalizability could be improved.
format	article
author	Deniz Alis Mert Yergin Ceren Alis Cagdas Topel Ozan Asmakutlu Omer Bagcilar Yeseren Deniz Senli Ahmet Ustundag Vefa Salt Sebahat Nacar Dogan Murat Velioglu Hakan Hatem Selcuk Batuhan Kara Ilkay Oksuz Osman Kizilkilic Ercan Karaarslan
author_facet	Deniz Alis Mert Yergin Ceren Alis Cagdas Topel Ozan Asmakutlu Omer Bagcilar Yeseren Deniz Senli Ahmet Ustundag Vefa Salt Sebahat Nacar Dogan Murat Velioglu Hakan Hatem Selcuk Batuhan Kara Ilkay Oksuz Osman Kizilkilic Ercan Karaarslan
author_sort	Deniz Alis
title	Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study
title_short	Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study
title_full	Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study
title_fullStr	Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study
title_full_unstemmed	Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study
title_sort	inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/897683b2837b4094b80466289ed7a30d
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Inter-vendor performance of deep learning in segmenting acute ischemic lesions on diffusion-weighted imaging: a multicenter study

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