Temporal profiling of depression vulnerability in a preclinical model of sustained depression

Abstract Major Depression is a prevalent mental disorder that is characterized by negative mood and reduced motivation, and frequently results in social withdrawal and memory-related deficits. Repeated stressors, such as adverse life events, increase the risk for development of the disorder. Consequ...

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Autores principales:	D. Riga, L. J. M. Schmitz, W. J. G. Hoogendijk, A. B. Smit, S. Spijker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8978e033a81646b38f2596a77e5bec25
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spelling	oai:doaj.org-article:8978e033a81646b38f2596a77e5bec252021-12-02T16:06:57ZTemporal profiling of depression vulnerability in a preclinical model of sustained depression10.1038/s41598-017-06984-52045-2322https://doaj.org/article/8978e033a81646b38f2596a77e5bec252017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06984-5https://doaj.org/toc/2045-2322Abstract Major Depression is a prevalent mental disorder that is characterized by negative mood and reduced motivation, and frequently results in social withdrawal and memory-related deficits. Repeated stressors, such as adverse life events, increase the risk for development of the disorder. Consequently, individual variability in stress response greatly weighs on depression-vulnerability and -resilience. Here, we employed the social defeat-induced persistent stress (SDPS) paradigm to identify depression-prone individuals and to examine the temporal development of depression in the months following exposure to brief defeat stress. Male Wistar rats were socially defeated (5 defeat episodes) and single-housed for a prolonged period of time (~24 weeks). We assessed the emergence of a sustained depressive-like state by repeatedly evaluating social motivation (social approach avoidance) and spatial memory (object place recognition) in SDPS rats during the isolation period. Individual variability in the effects of SDPS yielded two extreme subpopulations: an SDPS-prone group that showed gradual affective and cognitive deterioration in terms of social approach and memory retention, and a SDPS-resilient group that did not develop this phenotype. Notably, in SDPS-prone individuals, the affective deficits preceded later cognitive impairments, providing a novel temporal profile of the development of pathology in this preclinical model of sustained depression.D. RigaL. J. M. SchmitzW. J. G. HoogendijkA. B. SmitS. SpijkerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. Riga L. J. M. Schmitz W. J. G. Hoogendijk A. B. Smit S. Spijker Temporal profiling of depression vulnerability in a preclinical model of sustained depression
description	Abstract Major Depression is a prevalent mental disorder that is characterized by negative mood and reduced motivation, and frequently results in social withdrawal and memory-related deficits. Repeated stressors, such as adverse life events, increase the risk for development of the disorder. Consequently, individual variability in stress response greatly weighs on depression-vulnerability and -resilience. Here, we employed the social defeat-induced persistent stress (SDPS) paradigm to identify depression-prone individuals and to examine the temporal development of depression in the months following exposure to brief defeat stress. Male Wistar rats were socially defeated (5 defeat episodes) and single-housed for a prolonged period of time (~24 weeks). We assessed the emergence of a sustained depressive-like state by repeatedly evaluating social motivation (social approach avoidance) and spatial memory (object place recognition) in SDPS rats during the isolation period. Individual variability in the effects of SDPS yielded two extreme subpopulations: an SDPS-prone group that showed gradual affective and cognitive deterioration in terms of social approach and memory retention, and a SDPS-resilient group that did not develop this phenotype. Notably, in SDPS-prone individuals, the affective deficits preceded later cognitive impairments, providing a novel temporal profile of the development of pathology in this preclinical model of sustained depression.
format	article
author	D. Riga L. J. M. Schmitz W. J. G. Hoogendijk A. B. Smit S. Spijker
author_facet	D. Riga L. J. M. Schmitz W. J. G. Hoogendijk A. B. Smit S. Spijker
author_sort	D. Riga
title	Temporal profiling of depression vulnerability in a preclinical model of sustained depression
title_short	Temporal profiling of depression vulnerability in a preclinical model of sustained depression
title_full	Temporal profiling of depression vulnerability in a preclinical model of sustained depression
title_fullStr	Temporal profiling of depression vulnerability in a preclinical model of sustained depression
title_full_unstemmed	Temporal profiling of depression vulnerability in a preclinical model of sustained depression
title_sort	temporal profiling of depression vulnerability in a preclinical model of sustained depression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8978e033a81646b38f2596a77e5bec25
work_keys_str_mv	AT driga temporalprofilingofdepressionvulnerabilityinapreclinicalmodelofsustaineddepression AT ljmschmitz temporalprofilingofdepressionvulnerabilityinapreclinicalmodelofsustaineddepression AT wjghoogendijk temporalprofilingofdepressionvulnerabilityinapreclinicalmodelofsustaineddepression AT absmit temporalprofilingofdepressionvulnerabilityinapreclinicalmodelofsustaineddepression AT sspijker temporalprofilingofdepressionvulnerabilityinapreclinicalmodelofsustaineddepression
_version_	1718384788850606080

Temporal profiling of depression vulnerability in a preclinical model of sustained depression

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