Hypothermia ameliorates blast-related lifespan reduction of C. elegans

Abstract Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In a Caenorhabditis elegans model, we demonstrate a dose-dependent reduction...

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Autores principales:	Nicholas B. Angstman, Hans-Georg Frank, Christoph Schmitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/897918e21d0d4e06ab4a6f8d802b27a4
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spelling	oai:doaj.org-article:897918e21d0d4e06ab4a6f8d802b27a42021-12-02T15:08:44ZHypothermia ameliorates blast-related lifespan reduction of C. elegans10.1038/s41598-018-28910-z2045-2322https://doaj.org/article/897918e21d0d4e06ab4a6f8d802b27a42018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28910-zhttps://doaj.org/toc/2045-2322Abstract Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In a Caenorhabditis elegans model, we demonstrate a dose-dependent reduction in lifespan following exposure to blast-like shock waves. Using polyvinyl alcohol, we show that cavitation is a key injurious factor in the damaging shock wave component. Short and long lifespan C. elegans mutants demonstrated the interaction of genetic and environmental longevity-determining factors. Hypothermia reduced the long term effect of shock wave exposure. Thus, we present an effective C. elegans model of long term effects of blast-related mild traumatic brain injury, as well as evidence of the merit of therapeutic hypothermia as a therapy option following blast exposure.Nicholas B. AngstmanHans-Georg FrankChristoph SchmitzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-5 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicholas B. Angstman Hans-Georg Frank Christoph Schmitz Hypothermia ameliorates blast-related lifespan reduction of C. elegans
description	Abstract Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In a Caenorhabditis elegans model, we demonstrate a dose-dependent reduction in lifespan following exposure to blast-like shock waves. Using polyvinyl alcohol, we show that cavitation is a key injurious factor in the damaging shock wave component. Short and long lifespan C. elegans mutants demonstrated the interaction of genetic and environmental longevity-determining factors. Hypothermia reduced the long term effect of shock wave exposure. Thus, we present an effective C. elegans model of long term effects of blast-related mild traumatic brain injury, as well as evidence of the merit of therapeutic hypothermia as a therapy option following blast exposure.
format	article
author	Nicholas B. Angstman Hans-Georg Frank Christoph Schmitz
author_facet	Nicholas B. Angstman Hans-Georg Frank Christoph Schmitz
author_sort	Nicholas B. Angstman
title	Hypothermia ameliorates blast-related lifespan reduction of C. elegans
title_short	Hypothermia ameliorates blast-related lifespan reduction of C. elegans
title_full	Hypothermia ameliorates blast-related lifespan reduction of C. elegans
title_fullStr	Hypothermia ameliorates blast-related lifespan reduction of C. elegans
title_full_unstemmed	Hypothermia ameliorates blast-related lifespan reduction of C. elegans
title_sort	hypothermia ameliorates blast-related lifespan reduction of c. elegans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/897918e21d0d4e06ab4a6f8d802b27a4
work_keys_str_mv	AT nicholasbangstman hypothermiaamelioratesblastrelatedlifespanreductionofcelegans AT hansgeorgfrank hypothermiaamelioratesblastrelatedlifespanreductionofcelegans AT christophschmitz hypothermiaamelioratesblastrelatedlifespanreductionofcelegans
_version_	1718388011106828288

Hypothermia ameliorates blast-related lifespan reduction of C. elegans

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