Hypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature

Objective: To review the indications and clinical evidence supporting hypoglossal nerve stimulation (HNS) therapy for the treatment of moderate-to-severe obstructive sleep apnea (OSA). Methods: Peer reviewed literature on hypoglossal nerve stimulation therapy for obstructive sleep apnea from 2001 to...

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Autores principales:	Christina M. Wray, Erica R. Thaler
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/897a3f4ffc3641efbeafb00ee87f3f27
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spelling	oai:doaj.org-article:897a3f4ffc3641efbeafb00ee87f3f272021-12-02T14:14:53ZHypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature2095-881110.1016/j.wjorl.2016.11.005https://doaj.org/article/897a3f4ffc3641efbeafb00ee87f3f272016-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116300737https://doaj.org/toc/2095-8811Objective: To review the indications and clinical evidence supporting hypoglossal nerve stimulation (HNS) therapy for the treatment of moderate-to-severe obstructive sleep apnea (OSA). Methods: Peer reviewed literature on hypoglossal nerve stimulation therapy for obstructive sleep apnea from 2001 to 2016. Results: The only currently FDA-approved HNS device for the treatment of moderate-to-severe OSA is produced by Inspire Medical Systems, which recently published its 36-month outcomes data from its Stimulation Therapy for Apnea Reduction (STAR) trial. HNS therapy is currently indicated for moderate-to-severe OSA patients who are CPAP-intolerant, have a body mass index <32, apnea-hypopnea index <50, and without a concentric pattern of upper airway collapse on sleep endoscopy. Conclusions: Data from the STAR trial suggests that a subset of OSA patients can achieve a significant therapeutic response from hypoglossal nerve stimulation. However, these results may be limited in their generalizability to the broader OSA population. Keywords: Hypoglossal nerve stimulation, Obstructive sleep apnea, Upper airway stimulation, CPAP-intolerant, NeurostimulationChristina M. WrayErica R. ThalerKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 4, Pp 230-233 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Christina M. Wray Erica R. Thaler Hypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature
description	Objective: To review the indications and clinical evidence supporting hypoglossal nerve stimulation (HNS) therapy for the treatment of moderate-to-severe obstructive sleep apnea (OSA). Methods: Peer reviewed literature on hypoglossal nerve stimulation therapy for obstructive sleep apnea from 2001 to 2016. Results: The only currently FDA-approved HNS device for the treatment of moderate-to-severe OSA is produced by Inspire Medical Systems, which recently published its 36-month outcomes data from its Stimulation Therapy for Apnea Reduction (STAR) trial. HNS therapy is currently indicated for moderate-to-severe OSA patients who are CPAP-intolerant, have a body mass index <32, apnea-hypopnea index <50, and without a concentric pattern of upper airway collapse on sleep endoscopy. Conclusions: Data from the STAR trial suggests that a subset of OSA patients can achieve a significant therapeutic response from hypoglossal nerve stimulation. However, these results may be limited in their generalizability to the broader OSA population. Keywords: Hypoglossal nerve stimulation, Obstructive sleep apnea, Upper airway stimulation, CPAP-intolerant, Neurostimulation
format	article
author	Christina M. Wray Erica R. Thaler
author_facet	Christina M. Wray Erica R. Thaler
author_sort	Christina M. Wray
title	Hypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature
title_short	Hypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature
title_full	Hypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature
title_fullStr	Hypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature
title_full_unstemmed	Hypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature
title_sort	hypoglossal nerve stimulation for obstructive sleep apnea: a review of the literature
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/897a3f4ffc3641efbeafb00ee87f3f27
work_keys_str_mv	AT christinamwray hypoglossalnervestimulationforobstructivesleepapneaareviewoftheliterature AT ericarthaler hypoglossalnervestimulationforobstructivesleepapneaareviewoftheliterature
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Hypoglossal nerve stimulation for obstructive sleep apnea: A review of the literature

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