Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder

The novel coronavirus named SARS-CoV-2 has emerged at the end of 2019, which causes coronavirus disease (COVID-2019). Recent case reports of COVID-19 patients have revealed the onset of Parkinson's disease (PD) symptoms in patients who do not have a family history of the PD. However, till recen...

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Autores principales:	Hongxia Zhao, Qinghua Zhang, Huifang Chen, Md Rezanur Rahman, Hossain Md Faruquee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 Parkinson’s disorder Blood gene expression Transcriptional signatures Molecular pathways Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/897e46b057864cdc9ac003627fd7a254
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spelling	oai:doaj.org-article:897e46b057864cdc9ac003627fd7a2542021-11-20T04:56:34ZIntegrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder1319-562X10.1016/j.sjbs.2021.07.074https://doaj.org/article/897e46b057864cdc9ac003627fd7a2542021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21006562https://doaj.org/toc/1319-562XThe novel coronavirus named SARS-CoV-2 has emerged at the end of 2019, which causes coronavirus disease (COVID-2019). Recent case reports of COVID-19 patients have revealed the onset of Parkinson's disease (PD) symptoms in patients who do not have a family history of the PD. However, till recently, no genetic impact or mechanisms that may induce Parkinsonism in COVID-19 patients or after COVID-19 have been found.. This study aimed to detect the commonly dysregulated genes, transcriptional regulators, and pathways between PD and COVID-19. We integrated genome-wide transcriptomic datasets from peripheral blood mononuclear cells (PBMC) samples from COVID-19 and PD and associated pathways. Our study revealed 81 upregulated and 48 downregulated differentially expressed genes (DEGs) shared between PD and COVID-19. These dysregulated genes were involved in key pathways “mitochondrion structure organization”, “cell activation in immune response”, and “signalling by interleukins”. Our analysis showed RELA, TP53 and SP1 TFs that may regulate the upregulated DEGs. We have discovered key dysregulated genes and characterized the biological processes of commonly dysregulated in COVID-19 and PD, which could be used for the design of personalized treatment of PD following COVID-19.Hongxia ZhaoQinghua ZhangHuifang ChenMd Rezanur RahmanHossain Md FaruqueeElsevierarticleCOVID-19Parkinson’s disorderBlood gene expressionTranscriptional signaturesMolecular pathwaysBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 6939-6945 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Parkinson’s disorder Blood gene expression Transcriptional signatures Molecular pathways Biology (General) QH301-705.5
spellingShingle	COVID-19 Parkinson’s disorder Blood gene expression Transcriptional signatures Molecular pathways Biology (General) QH301-705.5 Hongxia Zhao Qinghua Zhang Huifang Chen Md Rezanur Rahman Hossain Md Faruquee Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder
description	The novel coronavirus named SARS-CoV-2 has emerged at the end of 2019, which causes coronavirus disease (COVID-2019). Recent case reports of COVID-19 patients have revealed the onset of Parkinson's disease (PD) symptoms in patients who do not have a family history of the PD. However, till recently, no genetic impact or mechanisms that may induce Parkinsonism in COVID-19 patients or after COVID-19 have been found.. This study aimed to detect the commonly dysregulated genes, transcriptional regulators, and pathways between PD and COVID-19. We integrated genome-wide transcriptomic datasets from peripheral blood mononuclear cells (PBMC) samples from COVID-19 and PD and associated pathways. Our study revealed 81 upregulated and 48 downregulated differentially expressed genes (DEGs) shared between PD and COVID-19. These dysregulated genes were involved in key pathways “mitochondrion structure organization”, “cell activation in immune response”, and “signalling by interleukins”. Our analysis showed RELA, TP53 and SP1 TFs that may regulate the upregulated DEGs. We have discovered key dysregulated genes and characterized the biological processes of commonly dysregulated in COVID-19 and PD, which could be used for the design of personalized treatment of PD following COVID-19.
format	article
author	Hongxia Zhao Qinghua Zhang Huifang Chen Md Rezanur Rahman Hossain Md Faruquee
author_facet	Hongxia Zhao Qinghua Zhang Huifang Chen Md Rezanur Rahman Hossain Md Faruquee
author_sort	Hongxia Zhao
title	Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder
title_short	Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder
title_full	Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder
title_fullStr	Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder
title_full_unstemmed	Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder
title_sort	integrated multi-omics approach identified molecular mechanism and pathogenetic processes of covid-19 that affect patient with parkinson’s disorder
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/897e46b057864cdc9ac003627fd7a254
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Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder

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