Novel Peptide Therapeutic Approaches for Cancer Treatment

Peptides are increasingly being developed for use as therapeutics to treat many ailments, including cancer. Therapeutic peptides have the advantages of target specificity and low toxicity. The anticancer effects of a peptide can be the direct result of the peptide binding its intended target, or the...

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Autores principales:	Caroline M. Li, Pouya Haratipour, Robert G. Lingeman, J. Jefferson P. Perry, Long Gu, Robert J. Hickey, Linda H. Malkas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug delivery peptide therapeutic covalent-based peptide inhibitors PCNA Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/898ac45b5c99412aa0740ae2f675c8b1
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spelling	oai:doaj.org-article:898ac45b5c99412aa0740ae2f675c8b12021-11-25T17:08:47ZNovel Peptide Therapeutic Approaches for Cancer Treatment10.3390/cells101129082073-4409https://doaj.org/article/898ac45b5c99412aa0740ae2f675c8b12021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2908https://doaj.org/toc/2073-4409Peptides are increasingly being developed for use as therapeutics to treat many ailments, including cancer. Therapeutic peptides have the advantages of target specificity and low toxicity. The anticancer effects of a peptide can be the direct result of the peptide binding its intended target, or the peptide may be conjugated to a chemotherapy drug or radionuclide and used to target the agent to cancer cells. Peptides can be targeted to proteins on the cell surface, where the peptide–protein interaction can initiate internalization of the complex, or the peptide can be designed to directly cross the cell membrane. Peptides can induce cell death by numerous mechanisms including membrane disruption and subsequent necrosis, apoptosis, tumor angiogenesis inhibition, immune regulation, disruption of cell signaling pathways, cell cycle regulation, DNA repair pathways, or cell death pathways. Although using peptides as therapeutics has many advantages, peptides have the disadvantage of being easily degraded by proteases once administered and, depending on the mode of administration, often have difficulty being adsorbed into the blood stream. In this review, we discuss strategies recently developed to overcome these obstacles of peptide delivery and bioavailability. In addition, we present many examples of peptides developed to fight cancer.Caroline M. LiPouya HaratipourRobert G. LingemanJ. Jefferson P. PerryLong GuRobert J. HickeyLinda H. MalkasMDPI AGarticledrug deliverypeptide therapeuticcovalent-based peptide inhibitorsPCNABiology (General)QH301-705.5ENCells, Vol 10, Iss 2908, p 2908 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery peptide therapeutic covalent-based peptide inhibitors PCNA Biology (General) QH301-705.5
spellingShingle	drug delivery peptide therapeutic covalent-based peptide inhibitors PCNA Biology (General) QH301-705.5 Caroline M. Li Pouya Haratipour Robert G. Lingeman J. Jefferson P. Perry Long Gu Robert J. Hickey Linda H. Malkas Novel Peptide Therapeutic Approaches for Cancer Treatment
description	Peptides are increasingly being developed for use as therapeutics to treat many ailments, including cancer. Therapeutic peptides have the advantages of target specificity and low toxicity. The anticancer effects of a peptide can be the direct result of the peptide binding its intended target, or the peptide may be conjugated to a chemotherapy drug or radionuclide and used to target the agent to cancer cells. Peptides can be targeted to proteins on the cell surface, where the peptide–protein interaction can initiate internalization of the complex, or the peptide can be designed to directly cross the cell membrane. Peptides can induce cell death by numerous mechanisms including membrane disruption and subsequent necrosis, apoptosis, tumor angiogenesis inhibition, immune regulation, disruption of cell signaling pathways, cell cycle regulation, DNA repair pathways, or cell death pathways. Although using peptides as therapeutics has many advantages, peptides have the disadvantage of being easily degraded by proteases once administered and, depending on the mode of administration, often have difficulty being adsorbed into the blood stream. In this review, we discuss strategies recently developed to overcome these obstacles of peptide delivery and bioavailability. In addition, we present many examples of peptides developed to fight cancer.
format	article
author	Caroline M. Li Pouya Haratipour Robert G. Lingeman J. Jefferson P. Perry Long Gu Robert J. Hickey Linda H. Malkas
author_facet	Caroline M. Li Pouya Haratipour Robert G. Lingeman J. Jefferson P. Perry Long Gu Robert J. Hickey Linda H. Malkas
author_sort	Caroline M. Li
title	Novel Peptide Therapeutic Approaches for Cancer Treatment
title_short	Novel Peptide Therapeutic Approaches for Cancer Treatment
title_full	Novel Peptide Therapeutic Approaches for Cancer Treatment
title_fullStr	Novel Peptide Therapeutic Approaches for Cancer Treatment
title_full_unstemmed	Novel Peptide Therapeutic Approaches for Cancer Treatment
title_sort	novel peptide therapeutic approaches for cancer treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/898ac45b5c99412aa0740ae2f675c8b1
work_keys_str_mv	AT carolinemli novelpeptidetherapeuticapproachesforcancertreatment AT pouyaharatipour novelpeptidetherapeuticapproachesforcancertreatment AT robertglingeman novelpeptidetherapeuticapproachesforcancertreatment AT jjeffersonpperry novelpeptidetherapeuticapproachesforcancertreatment AT longgu novelpeptidetherapeuticapproachesforcancertreatment AT robertjhickey novelpeptidetherapeuticapproachesforcancertreatment AT lindahmalkas novelpeptidetherapeuticapproachesforcancertreatment
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Novel Peptide Therapeutic Approaches for Cancer Treatment

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