Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia

Yanping Wang,1,2 Xiaoling Zhang,2 Qiaobing Guan,2 Lihong Wan,2 Yahui Yi,2 Chun-Feng Liu1 1Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 2Department of Neurology, The Second Hospital of Jiaxing City, Jiaxing, Zhejiang Province, People&rs...

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Autores principales:	Wang Y, Zhang X, Guan Q, Wan L, Yi Y, Liu CF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/898d5acac4b440689a0dd302c197328a
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spelling	oai:doaj.org-article:898d5acac4b440689a0dd302c197328a2021-12-02T04:59:56ZAltered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia1178-2021https://doaj.org/article/898d5acac4b440689a0dd302c197328a2015-10-01T00:00:00Zhttps://www.dovepress.com/altered-regional-homogeneity-of-spontaneous-brain-activity-in-idiopath-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yanping Wang,1,2 Xiaoling Zhang,2 Qiaobing Guan,2 Lihong Wan,2 Yahui Yi,2 Chun-Feng Liu1 1Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 2Department of Neurology, The Second Hospital of Jiaxing City, Jiaxing, Zhejiang Province, People’s Republic of China Abstract: The pathophysiology of idiopathic trigeminal neuralgia (ITN) has conventionally been thought to be induced by neurovascular compression theory. Recent structural brain imaging evidence has suggested an additional central component for ITN pathophysiology. However, far less attention has been given to investigations of the basis of abnormal resting-state brain activity in these patients. The objective of this study was to investigate local brain activity in patients with ITN and its correlation with clinical variables of pain. Resting-state functional magnetic resonance imaging data from 17 patients with ITN and 19 age- and sex-matched healthy controls were analyzed using regional homogeneity (ReHo) analysis, which is a data-driven approach used to measure the regional synchronization of spontaneous brain activity. Patients with ITN had decreased ReHo in the left amygdala, right parahippocampal gyrus, and left cerebellum and increased ReHo in the right inferior temporal gyrus, right thalamus, right inferior parietal lobule, and left postcentral gyrus (corrected). Furthermore, the increase in ReHo in the left precentral gyrus was positively correlated with visual analog scale (r=0.54; P=0.002). Our study found abnormal functional homogeneity of intrinsic brain activity in several regions in ITN, suggesting the maladaptivity of the process of daily pain attacks and a central role for the pathophysiology of ITN. Keywords: trigeminal neuralgia, resting fMRI, brain, chronic pain, local connectivityWang YZhang XGuan QWan LYi YLiu CFDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2659-2666 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang Y Zhang X Guan Q Wan L Yi Y Liu CF Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia
description	Yanping Wang,1,2 Xiaoling Zhang,2 Qiaobing Guan,2 Lihong Wan,2 Yahui Yi,2 Chun-Feng Liu1 1Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 2Department of Neurology, The Second Hospital of Jiaxing City, Jiaxing, Zhejiang Province, People’s Republic of China Abstract: The pathophysiology of idiopathic trigeminal neuralgia (ITN) has conventionally been thought to be induced by neurovascular compression theory. Recent structural brain imaging evidence has suggested an additional central component for ITN pathophysiology. However, far less attention has been given to investigations of the basis of abnormal resting-state brain activity in these patients. The objective of this study was to investigate local brain activity in patients with ITN and its correlation with clinical variables of pain. Resting-state functional magnetic resonance imaging data from 17 patients with ITN and 19 age- and sex-matched healthy controls were analyzed using regional homogeneity (ReHo) analysis, which is a data-driven approach used to measure the regional synchronization of spontaneous brain activity. Patients with ITN had decreased ReHo in the left amygdala, right parahippocampal gyrus, and left cerebellum and increased ReHo in the right inferior temporal gyrus, right thalamus, right inferior parietal lobule, and left postcentral gyrus (corrected). Furthermore, the increase in ReHo in the left precentral gyrus was positively correlated with visual analog scale (r=0.54; P=0.002). Our study found abnormal functional homogeneity of intrinsic brain activity in several regions in ITN, suggesting the maladaptivity of the process of daily pain attacks and a central role for the pathophysiology of ITN. Keywords: trigeminal neuralgia, resting fMRI, brain, chronic pain, local connectivity
format	article
author	Wang Y Zhang X Guan Q Wan L Yi Y Liu CF
author_facet	Wang Y Zhang X Guan Q Wan L Yi Y Liu CF
author_sort	Wang Y
title	Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia
title_short	Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia
title_full	Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia
title_fullStr	Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia
title_full_unstemmed	Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia
title_sort	altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/898d5acac4b440689a0dd302c197328a
work_keys_str_mv	AT wangy alteredregionalhomogeneityofspontaneousbrainactivityinidiopathictrigeminalneuralgia AT zhangx alteredregionalhomogeneityofspontaneousbrainactivityinidiopathictrigeminalneuralgia AT guanq alteredregionalhomogeneityofspontaneousbrainactivityinidiopathictrigeminalneuralgia AT wanl alteredregionalhomogeneityofspontaneousbrainactivityinidiopathictrigeminalneuralgia AT yiy alteredregionalhomogeneityofspontaneousbrainactivityinidiopathictrigeminalneuralgia AT liucf alteredregionalhomogeneityofspontaneousbrainactivityinidiopathictrigeminalneuralgia
_version_	1718400901149884416

Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia

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