Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement

Purpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD).Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, artif...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kangcheng Liu, Yau Kei Chan, Xia Peng, Ruolan Yuan, Min Liao, Jingwen Liang, Xiangbo Tang, Yi Xu, Yingjun Cai, Qiangxiang Li, Hua Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dietary supplements meibomian gland dysfunction (MGD) dry eye Retaron® symptoms and signs Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/898edfc2afb441a2bbb7557b48ab9a13
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:898edfc2afb441a2bbb7557b48ab9a13
record_format	dspace
spelling	oai:doaj.org-article:898edfc2afb441a2bbb7557b48ab9a132021-11-12T05:27:27ZImproved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement2296-858X10.3389/fmed.2021.769132https://doaj.org/article/898edfc2afb441a2bbb7557b48ab9a132021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.769132/fullhttps://doaj.org/toc/2296-858XPurpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD).Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, artificial tears, and antibiotic ointment. After that, the patients received dietary supplementary or placebo daily for 12 weeks. The dry eye signs, function of MG, and visual quality of the patients were assessed at 4, 8, and 12 weeks after the treatment.Results: Twelve weeks after the treatment, patients who received dietary supplement had a significantly better improvement of dry eye symptoms, in terms of ocular surface diseases index and tear breaking-up time (TBUT), than those who received placebo (P < 0.05). The functions of MG, in terms of meibum quality and MG exclusion and MG obstruction scores, were significantly improved in both dietary supplement and placebo groups (P < 0.05). Patients who received dietary supplement had a significantly better improvement in the MG structure, in terms of acinar diameter and acinar density, than those who received placebo (P < 0.05). The number of inflammatory cells near MG was significantly lower in the dietary supplement group when compared with the placebo group (P < 0.05). The objective visual quality was significantly improved in the dietary supplement group, but not in the placebo group (P < 0.05).Conclusion: The dietary supplement can effectively improve the symptoms and signs of MGD-related dry eye, reduce the inflammatory reaction of MG, restore the gland structure, and indirectly improve the visual quality.Kangcheng LiuYau Kei ChanXia PengRuolan YuanMin LiaoJingwen LiangXiangbo TangYi XuYingjun CaiQiangxiang LiHua WangFrontiers Media S.A.articledietary supplementsmeibomian gland dysfunction (MGD)dry eyeRetaron®symptoms and signsMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dietary supplements meibomian gland dysfunction (MGD) dry eye Retaron® symptoms and signs Medicine (General) R5-920
spellingShingle	dietary supplements meibomian gland dysfunction (MGD) dry eye Retaron® symptoms and signs Medicine (General) R5-920 Kangcheng Liu Yau Kei Chan Xia Peng Ruolan Yuan Min Liao Jingwen Liang Xiangbo Tang Yi Xu Yingjun Cai Qiangxiang Li Hua Wang Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
description	Purpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD).Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, artificial tears, and antibiotic ointment. After that, the patients received dietary supplementary or placebo daily for 12 weeks. The dry eye signs, function of MG, and visual quality of the patients were assessed at 4, 8, and 12 weeks after the treatment.Results: Twelve weeks after the treatment, patients who received dietary supplement had a significantly better improvement of dry eye symptoms, in terms of ocular surface diseases index and tear breaking-up time (TBUT), than those who received placebo (P < 0.05). The functions of MG, in terms of meibum quality and MG exclusion and MG obstruction scores, were significantly improved in both dietary supplement and placebo groups (P < 0.05). Patients who received dietary supplement had a significantly better improvement in the MG structure, in terms of acinar diameter and acinar density, than those who received placebo (P < 0.05). The number of inflammatory cells near MG was significantly lower in the dietary supplement group when compared with the placebo group (P < 0.05). The objective visual quality was significantly improved in the dietary supplement group, but not in the placebo group (P < 0.05).Conclusion: The dietary supplement can effectively improve the symptoms and signs of MGD-related dry eye, reduce the inflammatory reaction of MG, restore the gland structure, and indirectly improve the visual quality.
format	article
author	Kangcheng Liu Yau Kei Chan Xia Peng Ruolan Yuan Min Liao Jingwen Liang Xiangbo Tang Yi Xu Yingjun Cai Qiangxiang Li Hua Wang
author_facet	Kangcheng Liu Yau Kei Chan Xia Peng Ruolan Yuan Min Liao Jingwen Liang Xiangbo Tang Yi Xu Yingjun Cai Qiangxiang Li Hua Wang
author_sort	Kangcheng Liu
title	Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_short	Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_full	Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_fullStr	Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_full_unstemmed	Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement
title_sort	improved dry eye symptoms and signs of patients with meibomian gland dysfunction by a dietary supplement
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/898edfc2afb441a2bbb7557b48ab9a13
work_keys_str_mv	AT kangchengliu improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT yaukeichan improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT xiapeng improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT ruolanyuan improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT minliao improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT jingwenliang improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT xiangbotang improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT yixu improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT yingjuncai improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT qiangxiangli improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement AT huawang improveddryeyesymptomsandsignsofpatientswithmeibomianglanddysfunctionbyadietarysupplement
_version_	1718431181836386304

Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement

Ejemplares similares