Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids

TNF signalling was reported to mediate resistance to EGFR inhibition in non-small cell lung cancer (NSCLC). Here, the authors examine the efficacy of a broad versus focused targeting of this resistance, and they show that a broad inhibitor of inflammation, prednisone is the most effective.

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Autores principales:	Ke Gong, Gao Guo, Nicole A. Beckley, Xiaoyao Yang, Yue Zhang, David E. Gerber, John D. Minna, Sandeep Burma, Dawen Zhao, Esra A. Akbay, Amyn A. Habib
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8990fc56283d450e992bf4f9c8feb77b
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spelling	oai:doaj.org-article:8990fc56283d450e992bf4f9c8feb77b2021-12-05T12:22:21ZComprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids10.1038/s41467-021-27276-72041-1723https://doaj.org/article/8990fc56283d450e992bf4f9c8feb77b2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27276-7https://doaj.org/toc/2041-1723TNF signalling was reported to mediate resistance to EGFR inhibition in non-small cell lung cancer (NSCLC). Here, the authors examine the efficacy of a broad versus focused targeting of this resistance, and they show that a broad inhibitor of inflammation, prednisone is the most effective.Ke GongGao GuoNicole A. BeckleyXiaoyao YangYue ZhangDavid E. GerberJohn D. MinnaSandeep BurmaDawen ZhaoEsra A. AkbayAmyn A. HabibNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ke Gong Gao Guo Nicole A. Beckley Xiaoyao Yang Yue Zhang David E. Gerber John D. Minna Sandeep Burma Dawen Zhao Esra A. Akbay Amyn A. Habib Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
description	TNF signalling was reported to mediate resistance to EGFR inhibition in non-small cell lung cancer (NSCLC). Here, the authors examine the efficacy of a broad versus focused targeting of this resistance, and they show that a broad inhibitor of inflammation, prednisone is the most effective.
format	article
author	Ke Gong Gao Guo Nicole A. Beckley Xiaoyao Yang Yue Zhang David E. Gerber John D. Minna Sandeep Burma Dawen Zhao Esra A. Akbay Amyn A. Habib
author_facet	Ke Gong Gao Guo Nicole A. Beckley Xiaoyao Yang Yue Zhang David E. Gerber John D. Minna Sandeep Burma Dawen Zhao Esra A. Akbay Amyn A. Habib
author_sort	Ke Gong
title	Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
title_short	Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
title_full	Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
title_fullStr	Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
title_full_unstemmed	Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
title_sort	comprehensive targeting of resistance to inhibition of rtk signaling pathways by using glucocorticoids
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8990fc56283d450e992bf4f9c8feb77b
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Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids

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