Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity

Mammals lose up to 80% of their finite oocyte supply during fetal development. Here the authors interrogate mechanisms of fetal oocyte attrition in mice, driven by the simultaneous upregulation of LINE-1 retrotransposon activity and inhibit these mechanisms to increase the functional ovarian reserve...

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Autores principales:	Marla E. Tharp, Safia Malki, Alex Bortvin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/899198e19fea4a179249e8db0b572ef3
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spelling	oai:doaj.org-article:899198e19fea4a179249e8db0b572ef32021-12-02T14:41:14ZMaximizing the ovarian reserve in mice by evading LINE-1 genotoxicity10.1038/s41467-019-14055-82041-1723https://doaj.org/article/899198e19fea4a179249e8db0b572ef32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14055-8https://doaj.org/toc/2041-1723Mammals lose up to 80% of their finite oocyte supply during fetal development. Here the authors interrogate mechanisms of fetal oocyte attrition in mice, driven by the simultaneous upregulation of LINE-1 retrotransposon activity and inhibit these mechanisms to increase the functional ovarian reserve.Marla E. TharpSafia MalkiAlex BortvinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marla E. Tharp Safia Malki Alex Bortvin Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
description	Mammals lose up to 80% of their finite oocyte supply during fetal development. Here the authors interrogate mechanisms of fetal oocyte attrition in mice, driven by the simultaneous upregulation of LINE-1 retrotransposon activity and inhibit these mechanisms to increase the functional ovarian reserve.
format	article
author	Marla E. Tharp Safia Malki Alex Bortvin
author_facet	Marla E. Tharp Safia Malki Alex Bortvin
author_sort	Marla E. Tharp
title	Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
title_short	Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
title_full	Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
title_fullStr	Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
title_full_unstemmed	Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
title_sort	maximizing the ovarian reserve in mice by evading line-1 genotoxicity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/899198e19fea4a179249e8db0b572ef3
work_keys_str_mv	AT marlaetharp maximizingtheovarianreserveinmicebyevadingline1genotoxicity AT safiamalki maximizingtheovarianreserveinmicebyevadingline1genotoxicity AT alexbortvin maximizingtheovarianreserveinmicebyevadingline1genotoxicity
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Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity

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