Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors
Chronic itch affects about 10% of the general population, however current treatments are largely ineffective. Here, the authors show that targeting of inhibitory α2 and α3GABAA receptors reduces itch in mice and in a canine model, suggesting this a potentially useful therapeutic approach.
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/8993328b421e431ca678a24d0b1b96fb |
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oai:doaj.org-article:8993328b421e431ca678a24d0b1b96fb2021-12-02T17:31:26ZItch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors10.1038/s41467-018-05709-02041-1723https://doaj.org/article/8993328b421e431ca678a24d0b1b96fb2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05709-0https://doaj.org/toc/2041-1723Chronic itch affects about 10% of the general population, however current treatments are largely ineffective. Here, the authors show that targeting of inhibitory α2 and α3GABAA receptors reduces itch in mice and in a canine model, suggesting this a potentially useful therapeutic approach.William T. RalveniusElena NeumannMartina PaganiMario A. AcuñaHendrik WildnerDietmar BenkeNina FischerAna RostaherSimon SchwagerMichael DetmarKatrin FrauenknechtAdriano AguzziJed Lee HubbsUwe RudolphClaude FavrotHanns Ulrich ZeilhoferNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q William T. Ralvenius Elena Neumann Martina Pagani Mario A. Acuña Hendrik Wildner Dietmar Benke Nina Fischer Ana Rostaher Simon Schwager Michael Detmar Katrin Frauenknecht Adriano Aguzzi Jed Lee Hubbs Uwe Rudolph Claude Favrot Hanns Ulrich Zeilhofer Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors |
| description |
Chronic itch affects about 10% of the general population, however current treatments are largely ineffective. Here, the authors show that targeting of inhibitory α2 and α3GABAA receptors reduces itch in mice and in a canine model, suggesting this a potentially useful therapeutic approach. |
| format |
article |
| author |
William T. Ralvenius Elena Neumann Martina Pagani Mario A. Acuña Hendrik Wildner Dietmar Benke Nina Fischer Ana Rostaher Simon Schwager Michael Detmar Katrin Frauenknecht Adriano Aguzzi Jed Lee Hubbs Uwe Rudolph Claude Favrot Hanns Ulrich Zeilhofer |
| author_facet |
William T. Ralvenius Elena Neumann Martina Pagani Mario A. Acuña Hendrik Wildner Dietmar Benke Nina Fischer Ana Rostaher Simon Schwager Michael Detmar Katrin Frauenknecht Adriano Aguzzi Jed Lee Hubbs Uwe Rudolph Claude Favrot Hanns Ulrich Zeilhofer |
| author_sort |
William T. Ralvenius |
| title |
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors |
| title_short |
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors |
| title_full |
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors |
| title_fullStr |
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors |
| title_full_unstemmed |
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors |
| title_sort |
itch suppression in mice and dogs by modulation of spinal α2 and α3gabaa receptors |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/8993328b421e431ca678a24d0b1b96fb |
| work_keys_str_mv |
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| _version_ |
1718380625818288128 |