Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

The soluble bioactive form of the transmembrane protein fibronectin type III domain containing 4 (sFNDC4) has anti-inflammatory effects and improves insulin sensitivity. Here the authors show that liver derived sFNDC4 signals through adipose tissue GPCR GPR116 to promote insulin-mediated glucose upt...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Anastasia Georgiadi, Valeria Lopez-Salazar, Rabih El- Merahbi, Rhoda Anane Karikari, Xiaochuan Ma, André Mourão, Katarina Klepac, Lea Bühler, Ana Jimena Alfaro, Isabell Kaczmarek, Adam Linford, Madeleen Bosma, Olga Shilkova, Olli Ritvos, Nobuhiro Nakamura, Shigehisa Hirose, Maximilian Lassi, Raffaele Teperino, Juliano Machado, Marcel Scheideler, Arne Dietrich, Arie Geerlof, Annette Feuchtinger, Andreas Blutke, Katrin Fischer, Timo Dirk Müller, Katharina Kessler, Torsten Schöneberg, Doreen Thor, Silke Hornemann, Michael Kruse, Peter Nawroth, Olga Pivovarova-Ramich, Andreas Friedrich Hermann Pfeiffer, Michael Sattler, Matthias Blüher, Stephan Herzig
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/899459e9671c4eeca6889de131d50098
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:899459e9671c4eeca6889de131d50098
record_format dspace
spelling oai:doaj.org-article:899459e9671c4eeca6889de131d500982021-12-02T16:51:29ZOrphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue10.1038/s41467-021-22579-12041-1723https://doaj.org/article/899459e9671c4eeca6889de131d500982021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22579-1https://doaj.org/toc/2041-1723The soluble bioactive form of the transmembrane protein fibronectin type III domain containing 4 (sFNDC4) has anti-inflammatory effects and improves insulin sensitivity. Here the authors show that liver derived sFNDC4 signals through adipose tissue GPCR GPR116 to promote insulin-mediated glucose uptake.Anastasia GeorgiadiValeria Lopez-SalazarRabih El- MerahbiRhoda Anane KarikariXiaochuan MaAndré MourãoKatarina KlepacLea BühlerAna Jimena AlfaroIsabell KaczmarekAdam LinfordMadeleen BosmaOlga ShilkovaOlli RitvosNobuhiro NakamuraShigehisa HiroseMaximilian LassiRaffaele TeperinoJuliano MachadoMarcel ScheidelerArne DietrichArie GeerlofAnnette FeuchtingerAndreas BlutkeKatrin FischerTimo Dirk MüllerKatharina KesslerTorsten SchönebergDoreen ThorSilke HornemannMichael KrusePeter NawrothOlga Pivovarova-RamichAndreas Friedrich Hermann PfeifferMichael SattlerMatthias BlüherStephan HerzigNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anastasia Georgiadi
Valeria Lopez-Salazar
Rabih El- Merahbi
Rhoda Anane Karikari
Xiaochuan Ma
André Mourão
Katarina Klepac
Lea Bühler
Ana Jimena Alfaro
Isabell Kaczmarek
Adam Linford
Madeleen Bosma
Olga Shilkova
Olli Ritvos
Nobuhiro Nakamura
Shigehisa Hirose
Maximilian Lassi
Raffaele Teperino
Juliano Machado
Marcel Scheideler
Arne Dietrich
Arie Geerlof
Annette Feuchtinger
Andreas Blutke
Katrin Fischer
Timo Dirk Müller
Katharina Kessler
Torsten Schöneberg
Doreen Thor
Silke Hornemann
Michael Kruse
Peter Nawroth
Olga Pivovarova-Ramich
Andreas Friedrich Hermann Pfeiffer
Michael Sattler
Matthias Blüher
Stephan Herzig
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue
description The soluble bioactive form of the transmembrane protein fibronectin type III domain containing 4 (sFNDC4) has anti-inflammatory effects and improves insulin sensitivity. Here the authors show that liver derived sFNDC4 signals through adipose tissue GPCR GPR116 to promote insulin-mediated glucose uptake.
format article
author Anastasia Georgiadi
Valeria Lopez-Salazar
Rabih El- Merahbi
Rhoda Anane Karikari
Xiaochuan Ma
André Mourão
Katarina Klepac
Lea Bühler
Ana Jimena Alfaro
Isabell Kaczmarek
Adam Linford
Madeleen Bosma
Olga Shilkova
Olli Ritvos
Nobuhiro Nakamura
Shigehisa Hirose
Maximilian Lassi
Raffaele Teperino
Juliano Machado
Marcel Scheideler
Arne Dietrich
Arie Geerlof
Annette Feuchtinger
Andreas Blutke
Katrin Fischer
Timo Dirk Müller
Katharina Kessler
Torsten Schöneberg
Doreen Thor
Silke Hornemann
Michael Kruse
Peter Nawroth
Olga Pivovarova-Ramich
Andreas Friedrich Hermann Pfeiffer
Michael Sattler
Matthias Blüher
Stephan Herzig
author_facet Anastasia Georgiadi
Valeria Lopez-Salazar
Rabih El- Merahbi
Rhoda Anane Karikari
Xiaochuan Ma
André Mourão
Katarina Klepac
Lea Bühler
Ana Jimena Alfaro
Isabell Kaczmarek
Adam Linford
Madeleen Bosma
Olga Shilkova
Olli Ritvos
Nobuhiro Nakamura
Shigehisa Hirose
Maximilian Lassi
Raffaele Teperino
Juliano Machado
Marcel Scheideler
Arne Dietrich
Arie Geerlof
Annette Feuchtinger
Andreas Blutke
Katrin Fischer
Timo Dirk Müller
Katharina Kessler
Torsten Schöneberg
Doreen Thor
Silke Hornemann
Michael Kruse
Peter Nawroth
Olga Pivovarova-Ramich
Andreas Friedrich Hermann Pfeiffer
Michael Sattler
Matthias Blüher
Stephan Herzig
author_sort Anastasia Georgiadi
title Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue
title_short Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue
title_full Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue
title_fullStr Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue
title_full_unstemmed Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue
title_sort orphan gpr116 mediates the insulin sensitizing effects of the hepatokine fndc4 in adipose tissue
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/899459e9671c4eeca6889de131d50098
work_keys_str_mv AT anastasiageorgiadi orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT valerialopezsalazar orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT rabihelmerahbi orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT rhodaananekarikari orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT xiaochuanma orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT andremourao orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT katarinaklepac orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT leabuhler orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT anajimenaalfaro orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT isabellkaczmarek orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT adamlinford orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT madeleenbosma orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT olgashilkova orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT olliritvos orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT nobuhironakamura orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT shigehisahirose orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT maximilianlassi orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT raffaeleteperino orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT julianomachado orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT marcelscheideler orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT arnedietrich orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT ariegeerlof orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT annettefeuchtinger orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT andreasblutke orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT katrinfischer orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT timodirkmuller orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT katharinakessler orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT torstenschoneberg orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT doreenthor orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT silkehornemann orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT michaelkruse orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT peternawroth orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT olgapivovarovaramich orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT andreasfriedrichhermannpfeiffer orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT michaelsattler orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT matthiasbluher orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
AT stephanherzig orphangpr116mediatestheinsulinsensitizingeffectsofthehepatokinefndc4inadiposetissue
_version_ 1718382931203850240

Ejemplares similares