Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis
Yue-Long Xu,1 Yuan-Yuan Hu,2 Ji-Wei Li,1 Lan Zhou,3 Li Li,1 Yu-Ming Niu21Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, People’s Republic of China; 2Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hu...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/899cae035e8a4ae588904a080d41954a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:899cae035e8a4ae588904a080d41954a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:899cae035e8a4ae588904a080d41954a2021-12-02T06:49:13ZAldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis1178-2021https://doaj.org/article/899cae035e8a4ae588904a080d41954a2019-04-01T00:00:00Zhttps://www.dovepress.com/aldehyde-dehydrogenase-2-rs671ggta-polymorphism-and-ischemic-stroke-ri-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yue-Long Xu,1 Yuan-Yuan Hu,2 Ji-Wei Li,1 Lan Zhou,3 Li Li,1 Yu-Ming Niu21Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, People’s Republic of China; 2Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, People’s Republic of China; 3Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, People’s Republic of ChinaIntroduction: Recently, molecular epidemiological studies have suggested that aldehyde dehydrogenase 2 (ALDH2) rs671 G>A polymorphism may be a risk factor for ischemic stroke (IS). However, the results reported have not been consistent.Methods: We conducted the meta-analysis to explore the precise association between ALDH2 rs671 G>A polymorphism and IS risk. Five online databases were searched and the relative studies were reviewed from inception to October 1, 2018. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated in each genetic model of the general and subgroup. Furthermore, the heterogeneity, accumulative analyses, sensitivity analyses and publication bias were calculated simultaneously.Results: Overall, nine case-control studies involving 6,129 subjects were included in this meta-analysis. All studies were focused on the Chinese population and some significant associations were found between ALDH2 rs671 G>A polymorphism and IS risk (A vs G: OR=1.29, 95% CI=1.01–1.65, P=0.04, I2=78.2%; AA vs GG: OR=1.86, 95% CI=1.27–2.21, P<0.01, I2=11.3%; AA vs GG + GA: OR=1.67, 95% CI=1.27–2.19, P<0.01, I2=0%). Some significant and similar results were also observed in the subgroup analysis.Conclusion: Our meta-analysis indicates that the ALDH2 rs671 G>A polymorphism may play an important role in the occurrence of IS by reducing the activity of ALDH2 and interfering with the metabolic processes involving acetaldehyde.Keywords: aldehyde dehydrogenase 2, rs671, ischemic stroke, polymorphism, meta-analysisXu YLHu YYLi JWZhou LLi LNiu YMDove Medical PressarticleAldehyde dehydrogenase 2rs671ischemic strokepolymorphismmeta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1015-1029 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Aldehyde dehydrogenase 2 rs671 ischemic stroke polymorphism meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Aldehyde dehydrogenase 2 rs671 ischemic stroke polymorphism meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xu YL Hu YY Li JW Zhou L Li L Niu YM Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis |
| description |
Yue-Long Xu,1 Yuan-Yuan Hu,2 Ji-Wei Li,1 Lan Zhou,3 Li Li,1 Yu-Ming Niu21Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, People’s Republic of China; 2Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, People’s Republic of China; 3Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, People’s Republic of ChinaIntroduction: Recently, molecular epidemiological studies have suggested that aldehyde dehydrogenase 2 (ALDH2) rs671 G>A polymorphism may be a risk factor for ischemic stroke (IS). However, the results reported have not been consistent.Methods: We conducted the meta-analysis to explore the precise association between ALDH2 rs671 G>A polymorphism and IS risk. Five online databases were searched and the relative studies were reviewed from inception to October 1, 2018. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated in each genetic model of the general and subgroup. Furthermore, the heterogeneity, accumulative analyses, sensitivity analyses and publication bias were calculated simultaneously.Results: Overall, nine case-control studies involving 6,129 subjects were included in this meta-analysis. All studies were focused on the Chinese population and some significant associations were found between ALDH2 rs671 G>A polymorphism and IS risk (A vs G: OR=1.29, 95% CI=1.01–1.65, P=0.04, I2=78.2%; AA vs GG: OR=1.86, 95% CI=1.27–2.21, P<0.01, I2=11.3%; AA vs GG + GA: OR=1.67, 95% CI=1.27–2.19, P<0.01, I2=0%). Some significant and similar results were also observed in the subgroup analysis.Conclusion: Our meta-analysis indicates that the ALDH2 rs671 G>A polymorphism may play an important role in the occurrence of IS by reducing the activity of ALDH2 and interfering with the metabolic processes involving acetaldehyde.Keywords: aldehyde dehydrogenase 2, rs671, ischemic stroke, polymorphism, meta-analysis |
| format |
article |
| author |
Xu YL Hu YY Li JW Zhou L Li L Niu YM |
| author_facet |
Xu YL Hu YY Li JW Zhou L Li L Niu YM |
| author_sort |
Xu YL |
| title |
Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis |
| title_short |
Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis |
| title_full |
Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis |
| title_fullStr |
Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis |
| title_full_unstemmed |
Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis |
| title_sort |
aldehyde dehydrogenase 2 rs671g>a polymorphism and ischemic stroke risk in chinese population: a meta-analysis |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/899cae035e8a4ae588904a080d41954a |
| work_keys_str_mv |
AT xuyl aldehydedehydrogenase2rs671ggtapolymorphismandischemicstrokeriskinchinesepopulationametaanalysis AT huyy aldehydedehydrogenase2rs671ggtapolymorphismandischemicstrokeriskinchinesepopulationametaanalysis AT lijw aldehydedehydrogenase2rs671ggtapolymorphismandischemicstrokeriskinchinesepopulationametaanalysis AT zhoul aldehydedehydrogenase2rs671ggtapolymorphismandischemicstrokeriskinchinesepopulationametaanalysis AT lil aldehydedehydrogenase2rs671ggtapolymorphismandischemicstrokeriskinchinesepopulationametaanalysis AT niuym aldehydedehydrogenase2rs671ggtapolymorphismandischemicstrokeriskinchinesepopulationametaanalysis |
| _version_ |
1718399703524048896 |