Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas

The effects of cardiac disease on the intestine have been reported in humans but not in dogs. We investigated the effects of myxomatous mitral valve disease (MMVD), which is capable of causing congestion and tissue hypoperfusion, on the intestine in Chihuahuas, a breed frequently encountered in clin...

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Autores principales:	R. Araki, K. Iwanaga, Kazunori Ueda, M. Isaka
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Chihuahuas D-lactate intestinal complication intestinal fatty acid-binding protein intestinal mucosal injury markers myxomatous mitral valve disease Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/899ce3d513c4450aa398a2efb7e3aa9c
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spelling	oai:doaj.org-article:899ce3d513c4450aa398a2efb7e3aa9c2021-11-30T12:06:09ZIntestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas2297-176910.3389/fvets.2021.777579https://doaj.org/article/899ce3d513c4450aa398a2efb7e3aa9c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.777579/fullhttps://doaj.org/toc/2297-1769The effects of cardiac disease on the intestine have been reported in humans but not in dogs. We investigated the effects of myxomatous mitral valve disease (MMVD), which is capable of causing congestion and tissue hypoperfusion, on the intestine in Chihuahuas, a breed frequently encountered in clinical practice as the preferred breed for MMVD. In this study, 69 Chihuahuas were divided into four groups based on echocardiography and chest radiography: 19 healthy Chihuahuas (H) and 50 Chihuahuas with MMVD classified according to the ACVIM consensus (stage B1, B2, C/D). In all the cases, serum intestinal fatty acid-binding protein (I-FABP) and D/L-lactate concentrations, markers of intestinal mucosal injury, were measured. I-FABP was significantly higher in stage C/D Chihuahuas than in other groups (p < 0.05), and stage B2 was significantly higher than H (p < 0.05). D-lactate was significantly increased in stages B2 and C/D compared to H and stage B1 (p < 0.05). L-lactate was significantly higher in stage C/D Chihuahuas than in any other group (p < 0.05), and stage B2 was significantly higher than that in H and stage B1 (p < 0.05). Intestinal mucosal injury risk was significantly higher in Chihuahuas with heart failure due to MMVD, suggesting that the risk could increase with worsening heart disease. This is the first study to investigate the intestinal complications of MMVD, and further investigations a needed in the future.R. ArakiR. ArakiR. ArakiK. IwanagaKazunori UedaM. IsakaFrontiers Media S.A.articleChihuahuasD-lactateintestinal complicationintestinal fatty acid-binding proteinintestinal mucosal injury markersmyxomatous mitral valve diseaseVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chihuahuas D-lactate intestinal complication intestinal fatty acid-binding protein intestinal mucosal injury markers myxomatous mitral valve disease Veterinary medicine SF600-1100
spellingShingle	Chihuahuas D-lactate intestinal complication intestinal fatty acid-binding protein intestinal mucosal injury markers myxomatous mitral valve disease Veterinary medicine SF600-1100 R. Araki R. Araki R. Araki K. Iwanaga Kazunori Ueda M. Isaka Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas
description	The effects of cardiac disease on the intestine have been reported in humans but not in dogs. We investigated the effects of myxomatous mitral valve disease (MMVD), which is capable of causing congestion and tissue hypoperfusion, on the intestine in Chihuahuas, a breed frequently encountered in clinical practice as the preferred breed for MMVD. In this study, 69 Chihuahuas were divided into four groups based on echocardiography and chest radiography: 19 healthy Chihuahuas (H) and 50 Chihuahuas with MMVD classified according to the ACVIM consensus (stage B1, B2, C/D). In all the cases, serum intestinal fatty acid-binding protein (I-FABP) and D/L-lactate concentrations, markers of intestinal mucosal injury, were measured. I-FABP was significantly higher in stage C/D Chihuahuas than in other groups (p < 0.05), and stage B2 was significantly higher than H (p < 0.05). D-lactate was significantly increased in stages B2 and C/D compared to H and stage B1 (p < 0.05). L-lactate was significantly higher in stage C/D Chihuahuas than in any other group (p < 0.05), and stage B2 was significantly higher than that in H and stage B1 (p < 0.05). Intestinal mucosal injury risk was significantly higher in Chihuahuas with heart failure due to MMVD, suggesting that the risk could increase with worsening heart disease. This is the first study to investigate the intestinal complications of MMVD, and further investigations a needed in the future.
format	article
author	R. Araki R. Araki R. Araki K. Iwanaga Kazunori Ueda M. Isaka
author_facet	R. Araki R. Araki R. Araki K. Iwanaga Kazunori Ueda M. Isaka
author_sort	R. Araki
title	Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas
title_short	Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas
title_full	Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas
title_fullStr	Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas
title_full_unstemmed	Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas
title_sort	intestinal complication with myxomatous mitral valve diseases in chihuahuas
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/899ce3d513c4450aa398a2efb7e3aa9c
work_keys_str_mv	AT raraki intestinalcomplicationwithmyxomatousmitralvalvediseasesinchihuahuas AT raraki intestinalcomplicationwithmyxomatousmitralvalvediseasesinchihuahuas AT raraki intestinalcomplicationwithmyxomatousmitralvalvediseasesinchihuahuas AT kiwanaga intestinalcomplicationwithmyxomatousmitralvalvediseasesinchihuahuas AT kazunoriueda intestinalcomplicationwithmyxomatousmitralvalvediseasesinchihuahuas AT misaka intestinalcomplicationwithmyxomatousmitralvalvediseasesinchihuahuas
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Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas

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