The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies
Dysregulation of the immune system is associated with many pathologies, including cardiovascular diseases, diabetes, and cancer. To date, the most commonly used models in biomedical research are rodents, and despite the various advantages they offer, their use also raises numerous drawbacks. Recentl...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:89a608a5e64746bab473da488cd225842021-11-19T06:33:17ZThe Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies1664-322410.3389/fimmu.2021.791081https://doaj.org/article/89a608a5e64746bab473da488cd225842021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.791081/fullhttps://doaj.org/toc/1664-3224Dysregulation of the immune system is associated with many pathologies, including cardiovascular diseases, diabetes, and cancer. To date, the most commonly used models in biomedical research are rodents, and despite the various advantages they offer, their use also raises numerous drawbacks. Recently, another in vivo model, the chicken embryo and its chorioallantoic membrane, has re-emerged for various applications. This model has many benefits compared to other classical models, as it is cost-effective, time-efficient, and easier to use. In this review, we explain how the chicken embryo can be used as a model for immune-based studies, as it gradually develops an embryonic immune system, yet which is functionally similar to humans’. We mainly aim to describe the avian immune system, highlighting the differences and similarities with the human immune system, including the repertoire of lymphoid tissues, immune cells, and other key features. We also describe the general in ovo immune ontogeny. In conclusion, we expect that this review will help future studies better tailor their use of the chicken embryo model for testing specific experimental hypotheses or performing preclinical testing.Paul GarciaPaul GarciaPaul GarciaYan WangJean VialletZuzana Macek JilkovaZuzana Macek JilkovaZuzana Macek JilkovaFrontiers Media S.A.articleimmunologychickenchick embryochicken embryopreclinical modelchorioallantoic membraneImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
immunology chicken chick embryo chicken embryo preclinical model chorioallantoic membrane Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
immunology chicken chick embryo chicken embryo preclinical model chorioallantoic membrane Immunologic diseases. Allergy RC581-607 Paul Garcia Paul Garcia Paul Garcia Yan Wang Jean Viallet Zuzana Macek Jilkova Zuzana Macek Jilkova Zuzana Macek Jilkova The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies |
| description |
Dysregulation of the immune system is associated with many pathologies, including cardiovascular diseases, diabetes, and cancer. To date, the most commonly used models in biomedical research are rodents, and despite the various advantages they offer, their use also raises numerous drawbacks. Recently, another in vivo model, the chicken embryo and its chorioallantoic membrane, has re-emerged for various applications. This model has many benefits compared to other classical models, as it is cost-effective, time-efficient, and easier to use. In this review, we explain how the chicken embryo can be used as a model for immune-based studies, as it gradually develops an embryonic immune system, yet which is functionally similar to humans’. We mainly aim to describe the avian immune system, highlighting the differences and similarities with the human immune system, including the repertoire of lymphoid tissues, immune cells, and other key features. We also describe the general in ovo immune ontogeny. In conclusion, we expect that this review will help future studies better tailor their use of the chicken embryo model for testing specific experimental hypotheses or performing preclinical testing. |
| format |
article |
| author |
Paul Garcia Paul Garcia Paul Garcia Yan Wang Jean Viallet Zuzana Macek Jilkova Zuzana Macek Jilkova Zuzana Macek Jilkova |
| author_facet |
Paul Garcia Paul Garcia Paul Garcia Yan Wang Jean Viallet Zuzana Macek Jilkova Zuzana Macek Jilkova Zuzana Macek Jilkova |
| author_sort |
Paul Garcia |
| title |
The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies |
| title_short |
The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies |
| title_full |
The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies |
| title_fullStr |
The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies |
| title_full_unstemmed |
The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies |
| title_sort |
chicken embryo model: a novel and relevant model for immune-based studies |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/89a608a5e64746bab473da488cd22584 |
| work_keys_str_mv |
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