Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.

<h4>Objective</h4>We aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs).&l...

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Autores principales:	Fu-Chun Zhou, Wei-Min Hou, Chuan-Yue Wang, Gabor S Ungvari, Helen F K Chiu, Christoph U Correll, David H K Shum, David Man, Deng-Tang Liu, Yu-Tao Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89a6ad3bbbc847ba92eb8b5eb4363ff1
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spelling	oai:doaj.org-article:89a6ad3bbbc847ba92eb8b5eb4363ff12021-11-25T05:54:51ZProspective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.1932-620310.1371/journal.pone.0111562https://doaj.org/article/89a6ad3bbbc847ba92eb8b5eb4363ff12014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0111562https://doaj.org/toc/1932-6203<h4>Objective</h4>We aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs).<h4>Methods</h4>Forty-seven FES patients, 50 non-psychotic FDRs (23 offspring and 27 siblings) of patients with chronic schizophrenia (unrelated to the FES group) and 51 HCs were studied. The Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) was used to measure time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance. Other cognitive functions (involving respective memory and executive functions) were evaluated with standardized tests.<h4>Results</h4>After controlling for basic demographic characteristics including age, gender and educational level, there was a significant difference between FDRs, FES and HCs with respect to both TBPM (F(2,142) = 10.4, p<0.001) and EBPM (F(2,142) = 10.8, p<0.001). Multiple linear regression analyses revealed that lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the STROOP Word-Color Test (SWCT) contributed to TBPM impairment, while lower educational level and higher scores of the Color Trails Test-2 (CTT-2) contributed to EBPM deficit in FDRs.<h4>Conclusions</h4>FDRs share similar but attenuated prospective memory impairments with schizophrenia patients, suggesting that prospective memory deficits may represent an endophenotype of schizophrenia.Fu-Chun ZhouWei-Min HouChuan-Yue WangGabor S UngvariHelen F K ChiuChristoph U CorrellDavid H K ShumDavid ManDeng-Tang LiuYu-Tao XiangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 11, p e111562 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fu-Chun Zhou Wei-Min Hou Chuan-Yue Wang Gabor S Ungvari Helen F K Chiu Christoph U Correll David H K Shum David Man Deng-Tang Liu Yu-Tao Xiang Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
description	<h4>Objective</h4>We aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs).<h4>Methods</h4>Forty-seven FES patients, 50 non-psychotic FDRs (23 offspring and 27 siblings) of patients with chronic schizophrenia (unrelated to the FES group) and 51 HCs were studied. The Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) was used to measure time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance. Other cognitive functions (involving respective memory and executive functions) were evaluated with standardized tests.<h4>Results</h4>After controlling for basic demographic characteristics including age, gender and educational level, there was a significant difference between FDRs, FES and HCs with respect to both TBPM (F(2,142) = 10.4, p<0.001) and EBPM (F(2,142) = 10.8, p<0.001). Multiple linear regression analyses revealed that lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the STROOP Word-Color Test (SWCT) contributed to TBPM impairment, while lower educational level and higher scores of the Color Trails Test-2 (CTT-2) contributed to EBPM deficit in FDRs.<h4>Conclusions</h4>FDRs share similar but attenuated prospective memory impairments with schizophrenia patients, suggesting that prospective memory deficits may represent an endophenotype of schizophrenia.
format	article
author	Fu-Chun Zhou Wei-Min Hou Chuan-Yue Wang Gabor S Ungvari Helen F K Chiu Christoph U Correll David H K Shum David Man Deng-Tang Liu Yu-Tao Xiang
author_facet	Fu-Chun Zhou Wei-Min Hou Chuan-Yue Wang Gabor S Ungvari Helen F K Chiu Christoph U Correll David H K Shum David Man Deng-Tang Liu Yu-Tao Xiang
author_sort	Fu-Chun Zhou
title	Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
title_short	Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
title_full	Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
title_fullStr	Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
title_full_unstemmed	Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
title_sort	prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/89a6ad3bbbc847ba92eb8b5eb4363ff1
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Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.

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