Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial

Background: The first treatment option for major depressive disorder (MDD) is antidepressants, however, there is substantial demand for alternative therapies due to its low compliance and remission rates. This study was aimed to explore the effectiveness, safety, and feasibility of electroacupunctur...

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Autores principales:	Mikyung Kim, Eun-Ji Choi, O-Jin Kwon, Hyo-Ju Park, Ae-Ran Kim, Bok-Nam Seo, Sun-Yong Chung, Jun-Hwan Lee, Joo-Hee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Major depressive disorder Electroacupuncture Moxibustion Randomized controlled trial Miscellaneous systems and treatments RZ409.7-999
Acceso en línea:	https://doaj.org/article/89a6c1ec923649a29842b47e4d56b5b8
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spelling	oai:doaj.org-article:89a6c1ec923649a29842b47e4d56b5b82021-11-20T05:05:57ZElectroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial2213-422010.1016/j.imr.2021.100802https://doaj.org/article/89a6c1ec923649a29842b47e4d56b5b82022-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213422021000895https://doaj.org/toc/2213-4220Background: The first treatment option for major depressive disorder (MDD) is antidepressants, however, there is substantial demand for alternative therapies due to its low compliance and remission rates. This study was aimed to explore the effectiveness, safety, and feasibility of electroacupuncture plus moxibustion therapy for MDD. Methods: Thirty adults with MDD were randomly assigned to the treatment group (TG) or control group (CG). The TG was treated with electroacupuncture plus moxibustion, and the CG received sham interventions at non-acupoints for 8 weeks. The primary outcome measure was the intergroup difference of the mean change of total score of the Hamilton rating scale for depression (HRSD) between baseline and week 9. Secondary outcome measures were Beck's depression inventory, insomnia severity index, the state-trait anxiety inventory, the EuroQol-5 dimension index, the measure yourself medical outcome profile version 2, and frontal alpha asymmetry measured by electroencephalography. Adverse events (AEs) were monitored for safety assessment. Results: The primary outcome measure was not significantly different between the two groups (p=0.2641), although the scores of HRSD in both groups improved significantly after treatment. No significant difference was identified between groups in secondary outcome measures. The incidence of AE was not significantly different between the two groups (p=0.1067). Conclusion: A clinical trial using electroacupuncture plus moxibustion for MDD seems feasible. However, further studies with the larger size, adopting ideal controls are warranted to provide a confirmative conclusion to the efficacy and safety of electroacupuncture plus moxibustion for MDD. Trial registration: The protocol was registered at Korean Clinical Trial Registry (CRIS-KCT0001810)Mikyung KimEun-Ji ChoiO-Jin KwonHyo-Ju ParkAe-Ran KimBok-Nam SeoSun-Yong ChungJun-Hwan LeeJoo-Hee KimElsevierarticleMajor depressive disorderElectroacupunctureMoxibustionRandomized controlled trialMiscellaneous systems and treatmentsRZ409.7-999ENIntegrative Medicine Research, Vol 11, Iss 2, Pp 100802- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Major depressive disorder Electroacupuncture Moxibustion Randomized controlled trial Miscellaneous systems and treatments RZ409.7-999
spellingShingle	Major depressive disorder Electroacupuncture Moxibustion Randomized controlled trial Miscellaneous systems and treatments RZ409.7-999 Mikyung Kim Eun-Ji Choi O-Jin Kwon Hyo-Ju Park Ae-Ran Kim Bok-Nam Seo Sun-Yong Chung Jun-Hwan Lee Joo-Hee Kim Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial
description	Background: The first treatment option for major depressive disorder (MDD) is antidepressants, however, there is substantial demand for alternative therapies due to its low compliance and remission rates. This study was aimed to explore the effectiveness, safety, and feasibility of electroacupuncture plus moxibustion therapy for MDD. Methods: Thirty adults with MDD were randomly assigned to the treatment group (TG) or control group (CG). The TG was treated with electroacupuncture plus moxibustion, and the CG received sham interventions at non-acupoints for 8 weeks. The primary outcome measure was the intergroup difference of the mean change of total score of the Hamilton rating scale for depression (HRSD) between baseline and week 9. Secondary outcome measures were Beck's depression inventory, insomnia severity index, the state-trait anxiety inventory, the EuroQol-5 dimension index, the measure yourself medical outcome profile version 2, and frontal alpha asymmetry measured by electroencephalography. Adverse events (AEs) were monitored for safety assessment. Results: The primary outcome measure was not significantly different between the two groups (p=0.2641), although the scores of HRSD in both groups improved significantly after treatment. No significant difference was identified between groups in secondary outcome measures. The incidence of AE was not significantly different between the two groups (p=0.1067). Conclusion: A clinical trial using electroacupuncture plus moxibustion for MDD seems feasible. However, further studies with the larger size, adopting ideal controls are warranted to provide a confirmative conclusion to the efficacy and safety of electroacupuncture plus moxibustion for MDD. Trial registration: The protocol was registered at Korean Clinical Trial Registry (CRIS-KCT0001810)
format	article
author	Mikyung Kim Eun-Ji Choi O-Jin Kwon Hyo-Ju Park Ae-Ran Kim Bok-Nam Seo Sun-Yong Chung Jun-Hwan Lee Joo-Hee Kim
author_facet	Mikyung Kim Eun-Ji Choi O-Jin Kwon Hyo-Ju Park Ae-Ran Kim Bok-Nam Seo Sun-Yong Chung Jun-Hwan Lee Joo-Hee Kim
author_sort	Mikyung Kim
title	Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial
title_short	Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial
title_full	Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial
title_fullStr	Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial
title_full_unstemmed	Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial
title_sort	electroacupuncture plus moxibustion for major depressive disorder: a randomized, sham-controlled, pilot clinical trial
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/89a6c1ec923649a29842b47e4d56b5b8
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Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial

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