Genome-wide association study heterogeneous cohort homogenization via subject weight knock-down.

Population structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy phenotype ratio across the cohort, by decreasing th...

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Autores principales: André X C N Valente, Joseph Zischkau, Joo Heon Shin, Yuan Gao, Abhijit Sarkar
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/89abea5092914630b59f3419c1ea003c
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