A gene expression atlas for different kinds of stress in the mouse brain

Abstract Stressful experiences are part of everyday life and animals have evolved physiological and behavioral responses aimed at coping with stress and maintaining homeostasis. However, repeated or intense stress can induce maladaptive reactions leading to behavioral disorders. Adaptations in the b...

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Autores principales:	Tiziano Flati, Silvia Gioiosa, Giovanni Chillemi, Andrea Mele, Alberto Oliverio, Cecilia Mannironi, Arianna Rinaldi, Tiziana Castrignanò
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89af17cc98ca4456b8031adc366060b8
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spelling	oai:doaj.org-article:89af17cc98ca4456b8031adc366060b82021-12-02T13:34:01ZA gene expression atlas for different kinds of stress in the mouse brain10.1038/s41597-020-00772-z2052-4463https://doaj.org/article/89af17cc98ca4456b8031adc366060b82020-12-01T00:00:00Zhttps://doi.org/10.1038/s41597-020-00772-zhttps://doaj.org/toc/2052-4463Abstract Stressful experiences are part of everyday life and animals have evolved physiological and behavioral responses aimed at coping with stress and maintaining homeostasis. However, repeated or intense stress can induce maladaptive reactions leading to behavioral disorders. Adaptations in the brain, mediated by changes in gene expression, have a crucial role in the stress response. Recent years have seen a tremendous increase in studies on the transcriptional effects of stress. The input raw data are freely available from public repositories and represent a wealth of information for further global and integrative retrospective analyses. We downloaded from the Sequence Read Archive 751 samples (SRA-experiments), from 18 independent BioProjects studying the effects of different stressors on the brain transcriptome in mice. We performed a massive bioinformatics re-analysis applying a single, standardized pipeline for computing differential gene expression. This data mining allowed the identification of novel candidate stress-related genes and specific signatures associated with different stress conditions. The large amount of computational results produced was systematized in the interactive “Stress Mice Portal”.Tiziano FlatiSilvia GioiosaGiovanni ChillemiAndrea MeleAlberto OliverioCecilia MannironiArianna RinaldiTiziana CastrignanòNature PortfolioarticleScienceQENScientific Data, Vol 7, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tiziano Flati Silvia Gioiosa Giovanni Chillemi Andrea Mele Alberto Oliverio Cecilia Mannironi Arianna Rinaldi Tiziana Castrignanò A gene expression atlas for different kinds of stress in the mouse brain
description	Abstract Stressful experiences are part of everyday life and animals have evolved physiological and behavioral responses aimed at coping with stress and maintaining homeostasis. However, repeated or intense stress can induce maladaptive reactions leading to behavioral disorders. Adaptations in the brain, mediated by changes in gene expression, have a crucial role in the stress response. Recent years have seen a tremendous increase in studies on the transcriptional effects of stress. The input raw data are freely available from public repositories and represent a wealth of information for further global and integrative retrospective analyses. We downloaded from the Sequence Read Archive 751 samples (SRA-experiments), from 18 independent BioProjects studying the effects of different stressors on the brain transcriptome in mice. We performed a massive bioinformatics re-analysis applying a single, standardized pipeline for computing differential gene expression. This data mining allowed the identification of novel candidate stress-related genes and specific signatures associated with different stress conditions. The large amount of computational results produced was systematized in the interactive “Stress Mice Portal”.
format	article
author	Tiziano Flati Silvia Gioiosa Giovanni Chillemi Andrea Mele Alberto Oliverio Cecilia Mannironi Arianna Rinaldi Tiziana Castrignanò
author_facet	Tiziano Flati Silvia Gioiosa Giovanni Chillemi Andrea Mele Alberto Oliverio Cecilia Mannironi Arianna Rinaldi Tiziana Castrignanò
author_sort	Tiziano Flati
title	A gene expression atlas for different kinds of stress in the mouse brain
title_short	A gene expression atlas for different kinds of stress in the mouse brain
title_full	A gene expression atlas for different kinds of stress in the mouse brain
title_fullStr	A gene expression atlas for different kinds of stress in the mouse brain
title_full_unstemmed	A gene expression atlas for different kinds of stress in the mouse brain
title_sort	gene expression atlas for different kinds of stress in the mouse brain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/89af17cc98ca4456b8031adc366060b8
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A gene expression atlas for different kinds of stress in the mouse brain

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