Absorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning

Abstract Bioavailability of α-tocopherol varies with source, dose and duration of supplementation. The effect of source and dose of α-tocopherol on response of α-tocopherol stereoisomers in plasma and tissues of mink kits during the weaning period was studied. Twelve mink kits were euthanised in CO2...

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Autores principales:	Saman Lashkari, Tove N. Clausen, Leslie Foldager, Søren K. Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89b2e35506d84dfbbcee65cb05211189
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spelling	oai:doaj.org-article:89b2e35506d84dfbbcee65cb052111892021-12-02T14:16:49ZAbsorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning10.1038/s41598-020-80902-02045-2322https://doaj.org/article/89b2e35506d84dfbbcee65cb052111892021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80902-0https://doaj.org/toc/2045-2322Abstract Bioavailability of α-tocopherol varies with source, dose and duration of supplementation. The effect of source and dose of α-tocopherol on response of α-tocopherol stereoisomers in plasma and tissues of mink kits during the weaning period was studied. Twelve mink kits were euthanised in CO2 at the beginning of the experiment, and 156 mink kits (12 replicates per treatment group) were randomly assigned to thirteen treatment groups: no added α-tocopherol in the feed (0 dose) or four different doses (50, 75, 100 and 150 mg/kg of diet) of RRR-α-tocopherol (ALC), RRR-α-tocopheryl acetate (ACT) or all-rac-α-tocopheryl acetate (SYN). Six mink kits per treatment group were euthanised 3 weeks after initiation of the experiment, and the remaining six were euthanised 6 weeks after initiation of the experiment. The RRR-α-tocopherol content in plasma, liver, heart and lungs was affected by interaction between source and dose (P < 0.01 for all). The highest RRR-α-tocopherol content in plasma (13.6 µg/ml; LS-means for source across dose and week), liver (13.6 µg/mg), heart (7.6 µg/mg) and lungs (9.8 µg/mg) was observed in mink kits fed ALC. The RRR-α-tocopherol content in plasma and tissues depended on source and dose interaction and increased linearly with supplementation. In conclusion, the interaction between source and dose reveals a limitation in hydrolysis of ester bond in α-tocopheryl acetate in mink kits around weaning as the likely causative explanation for the higher response of ALC at the highest doses. Thus, considerable attention has to be paid to the source of α-tocopherol during weaning of mink kits fed a high dose of α-tocopherol.Saman LashkariTove N. ClausenLeslie FoldagerSøren K. JensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saman Lashkari Tove N. Clausen Leslie Foldager Søren K. Jensen Absorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning
description	Abstract Bioavailability of α-tocopherol varies with source, dose and duration of supplementation. The effect of source and dose of α-tocopherol on response of α-tocopherol stereoisomers in plasma and tissues of mink kits during the weaning period was studied. Twelve mink kits were euthanised in CO2 at the beginning of the experiment, and 156 mink kits (12 replicates per treatment group) were randomly assigned to thirteen treatment groups: no added α-tocopherol in the feed (0 dose) or four different doses (50, 75, 100 and 150 mg/kg of diet) of RRR-α-tocopherol (ALC), RRR-α-tocopheryl acetate (ACT) or all-rac-α-tocopheryl acetate (SYN). Six mink kits per treatment group were euthanised 3 weeks after initiation of the experiment, and the remaining six were euthanised 6 weeks after initiation of the experiment. The RRR-α-tocopherol content in plasma, liver, heart and lungs was affected by interaction between source and dose (P < 0.01 for all). The highest RRR-α-tocopherol content in plasma (13.6 µg/ml; LS-means for source across dose and week), liver (13.6 µg/mg), heart (7.6 µg/mg) and lungs (9.8 µg/mg) was observed in mink kits fed ALC. The RRR-α-tocopherol content in plasma and tissues depended on source and dose interaction and increased linearly with supplementation. In conclusion, the interaction between source and dose reveals a limitation in hydrolysis of ester bond in α-tocopheryl acetate in mink kits around weaning as the likely causative explanation for the higher response of ALC at the highest doses. Thus, considerable attention has to be paid to the source of α-tocopherol during weaning of mink kits fed a high dose of α-tocopherol.
format	article
author	Saman Lashkari Tove N. Clausen Leslie Foldager Søren K. Jensen
author_facet	Saman Lashkari Tove N. Clausen Leslie Foldager Søren K. Jensen
author_sort	Saman Lashkari
title	Absorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning
title_short	Absorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning
title_full	Absorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning
title_fullStr	Absorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning
title_full_unstemmed	Absorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning
title_sort	absorption of α-tocopheryl acetate is limited in mink kits (mustela vison) during weaning
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/89b2e35506d84dfbbcee65cb05211189
work_keys_str_mv	AT samanlashkari absorptionofatocopherylacetateislimitedinminkkitsmustelavisonduringweaning AT tovenclausen absorptionofatocopherylacetateislimitedinminkkitsmustelavisonduringweaning AT lesliefoldager absorptionofatocopherylacetateislimitedinminkkitsmustelavisonduringweaning AT sørenkjensen absorptionofatocopherylacetateislimitedinminkkitsmustelavisonduringweaning
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Absorption of α-tocopheryl acetate is limited in mink kits (Mustela vison) during weaning

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