4′-C-Aminoethoxy modification enhanced nuclease resistance of RNAs and improved thermal stability of RNA duplexes
We designed and synthesized RNAs containing 4′-C-aminoethoxy-2′-O-methyluridine (4′-AEoU), and compared their properties with those containing 4′-C-aminopropyl-2′-O-methyluridine (4′-APU). The RNA duplexes containing 4′-AEoU showed higher melting temperatures than those containing 4′-APU. The 4′-AEo...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Elsevier
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/89b5d49529b4487bb53b1ebe44d6c8cf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|