Influenza Virus Polymerase Mutation Stabilizes a Foreign Gene Inserted into the Virus Genome by Enhancing the Transcription/Replication Efficiency of the Modified Segment

Influenza Virus Polymerase Mutation Stabilizes a Foreign Gene Inserted into the Virus Genome by Enhancing the Transcription/Replication Efficiency of the Modified Segment

ABSTRACT We previously attempted to establish a reporter influenza virus by inserting the gene for the Venus fluorescent protein into the NS segment of influenza A/Puerto Rico/8/34 (PR8, H1N1) virus to yield WT-Venus-PR8. Although the inserted Venus gene was deleted during serial passages of WT-Venu...

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Autores principales: Yuri Furusawa, Shinya Yamada, Tiago Jose da Silva Lopes, Jayeeta Dutta, Zenab Khan, Divya Kriti, Harm van Bakel, Yoshihiro Kawaoka
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
foreign gene insertion
genetic stability
influenza
recombinant virus
virus polymerase
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/89b8272724554fa485028d1ea5512c61
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