A phylogenomic framework for charting the diversity and evolution of giant viruses

Large DNA viruses of the phylum Nucleocytoviricota have recently emerged as important members of ecosystems around the globe that challenge traditional views of viral complexity. Numerous members of this phylum that cannot be classified within established families have recently been reported, and th...

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Autores principales:	Frank O. Aylward, Mohammad Moniruzzaman, Anh D. Ha, Eugene V. Koonin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/89b876f1fb7a4fb0b272a4a35448d6af
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spelling	oai:doaj.org-article:89b876f1fb7a4fb0b272a4a35448d6af2021-11-18T05:34:19ZA phylogenomic framework for charting the diversity and evolution of giant viruses1544-91731545-7885https://doaj.org/article/89b876f1fb7a4fb0b272a4a35448d6af2021-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575486/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Large DNA viruses of the phylum Nucleocytoviricota have recently emerged as important members of ecosystems around the globe that challenge traditional views of viral complexity. Numerous members of this phylum that cannot be classified within established families have recently been reported, and there is presently a strong need for a robust phylogenomic and taxonomic framework for these viruses. Here, we report a comprehensive phylogenomic analysis of the Nucleocytoviricota, present a set of giant virus orthologous groups (GVOGs) together with a benchmarked reference phylogeny, and delineate a hierarchical taxonomy within this phylum. We show that the majority of Nucleocytoviricota diversity can be partitioned into 6 orders, 32 families, and 344 genera, substantially expanding the number of currently recognized taxonomic ranks for these viruses. We integrate our results within a taxonomy that has been adopted for all viruses to establish a unifying framework for the study of Nucleocytoviricota diversity, evolution, and environmental distribution. Giant viruses have transformed our understanding of viral complexity, but we lack a framework for examining their diversity in the biosphere. This study presents a phylogenomic resource for charting the diversity, ecology, and evolution of giant viruses.Frank O. AylwardMohammad MoniruzzamanAnh D. HaEugene V. KooninPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Frank O. Aylward Mohammad Moniruzzaman Anh D. Ha Eugene V. Koonin A phylogenomic framework for charting the diversity and evolution of giant viruses
description	Large DNA viruses of the phylum Nucleocytoviricota have recently emerged as important members of ecosystems around the globe that challenge traditional views of viral complexity. Numerous members of this phylum that cannot be classified within established families have recently been reported, and there is presently a strong need for a robust phylogenomic and taxonomic framework for these viruses. Here, we report a comprehensive phylogenomic analysis of the Nucleocytoviricota, present a set of giant virus orthologous groups (GVOGs) together with a benchmarked reference phylogeny, and delineate a hierarchical taxonomy within this phylum. We show that the majority of Nucleocytoviricota diversity can be partitioned into 6 orders, 32 families, and 344 genera, substantially expanding the number of currently recognized taxonomic ranks for these viruses. We integrate our results within a taxonomy that has been adopted for all viruses to establish a unifying framework for the study of Nucleocytoviricota diversity, evolution, and environmental distribution. Giant viruses have transformed our understanding of viral complexity, but we lack a framework for examining their diversity in the biosphere. This study presents a phylogenomic resource for charting the diversity, ecology, and evolution of giant viruses.
format	article
author	Frank O. Aylward Mohammad Moniruzzaman Anh D. Ha Eugene V. Koonin
author_facet	Frank O. Aylward Mohammad Moniruzzaman Anh D. Ha Eugene V. Koonin
author_sort	Frank O. Aylward
title	A phylogenomic framework for charting the diversity and evolution of giant viruses
title_short	A phylogenomic framework for charting the diversity and evolution of giant viruses
title_full	A phylogenomic framework for charting the diversity and evolution of giant viruses
title_fullStr	A phylogenomic framework for charting the diversity and evolution of giant viruses
title_full_unstemmed	A phylogenomic framework for charting the diversity and evolution of giant viruses
title_sort	phylogenomic framework for charting the diversity and evolution of giant viruses
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/89b876f1fb7a4fb0b272a4a35448d6af
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A phylogenomic framework for charting the diversity and evolution of giant viruses

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