Brain activation in motor sequence learning is related to the level of native cortical excitability.

Cortical excitability may be subject to changes through training and learning. Motor training can increase cortical excitability in motor cortex, and facilitation of motor cortical excitability has been shown to be positively correlated with improvements in performance in simple motor tasks. Thus co...

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Autores principales:	Silke Lissek, Guido S Vallana, Onur Güntürkün, Hubert Dinse, Martin Tegenthoff
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89b94d759c154d9585fe5e9610629cc9
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spelling	oai:doaj.org-article:89b94d759c154d9585fe5e9610629cc92021-11-18T07:49:15ZBrain activation in motor sequence learning is related to the level of native cortical excitability.1932-620310.1371/journal.pone.0061863https://doaj.org/article/89b94d759c154d9585fe5e9610629cc92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23613956/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cortical excitability may be subject to changes through training and learning. Motor training can increase cortical excitability in motor cortex, and facilitation of motor cortical excitability has been shown to be positively correlated with improvements in performance in simple motor tasks. Thus cortical excitability may tentatively be considered as a marker of learning and use-dependent plasticity. Previous studies focused on changes in cortical excitability brought about by learning processes, however, the relation between native levels of cortical excitability on the one hand and brain activation and behavioral parameters on the other is as yet unknown. In the present study we investigated the role of differential native motor cortical excitability for learning a motor sequencing task with regard to post-training changes in excitability, behavioral performance and involvement of brain regions. Our motor task required our participants to reproduce and improvise over a pre-learned motor sequence. Over both task conditions, participants with low cortical excitability (CElo) showed significantly higher BOLD activation in task-relevant brain regions than participants with high cortical excitability (CEhi). In contrast, CElo and CEhi groups did not exhibit differences in percentage of correct responses and improvisation level. Moreover, cortical excitability did not change significantly after learning and training in either group, with the exception of a significant decrease in facilitatory excitability in the CEhi group. The present data suggest that the native, unmanipulated level of cortical excitability is related to brain activation intensity, but not to performance quality. The higher BOLD mean signal intensity during the motor task might reflect a compensatory mechanism in CElo participants.Silke LissekGuido S VallanaOnur GüntürkünHubert DinseMartin TegenthoffPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61863 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Silke Lissek Guido S Vallana Onur Güntürkün Hubert Dinse Martin Tegenthoff Brain activation in motor sequence learning is related to the level of native cortical excitability.
description	Cortical excitability may be subject to changes through training and learning. Motor training can increase cortical excitability in motor cortex, and facilitation of motor cortical excitability has been shown to be positively correlated with improvements in performance in simple motor tasks. Thus cortical excitability may tentatively be considered as a marker of learning and use-dependent plasticity. Previous studies focused on changes in cortical excitability brought about by learning processes, however, the relation between native levels of cortical excitability on the one hand and brain activation and behavioral parameters on the other is as yet unknown. In the present study we investigated the role of differential native motor cortical excitability for learning a motor sequencing task with regard to post-training changes in excitability, behavioral performance and involvement of brain regions. Our motor task required our participants to reproduce and improvise over a pre-learned motor sequence. Over both task conditions, participants with low cortical excitability (CElo) showed significantly higher BOLD activation in task-relevant brain regions than participants with high cortical excitability (CEhi). In contrast, CElo and CEhi groups did not exhibit differences in percentage of correct responses and improvisation level. Moreover, cortical excitability did not change significantly after learning and training in either group, with the exception of a significant decrease in facilitatory excitability in the CEhi group. The present data suggest that the native, unmanipulated level of cortical excitability is related to brain activation intensity, but not to performance quality. The higher BOLD mean signal intensity during the motor task might reflect a compensatory mechanism in CElo participants.
format	article
author	Silke Lissek Guido S Vallana Onur Güntürkün Hubert Dinse Martin Tegenthoff
author_facet	Silke Lissek Guido S Vallana Onur Güntürkün Hubert Dinse Martin Tegenthoff
author_sort	Silke Lissek
title	Brain activation in motor sequence learning is related to the level of native cortical excitability.
title_short	Brain activation in motor sequence learning is related to the level of native cortical excitability.
title_full	Brain activation in motor sequence learning is related to the level of native cortical excitability.
title_fullStr	Brain activation in motor sequence learning is related to the level of native cortical excitability.
title_full_unstemmed	Brain activation in motor sequence learning is related to the level of native cortical excitability.
title_sort	brain activation in motor sequence learning is related to the level of native cortical excitability.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/89b94d759c154d9585fe5e9610629cc9
work_keys_str_mv	AT silkelissek brainactivationinmotorsequencelearningisrelatedtothelevelofnativecorticalexcitability AT guidosvallana brainactivationinmotorsequencelearningisrelatedtothelevelofnativecorticalexcitability AT onurgunturkun brainactivationinmotorsequencelearningisrelatedtothelevelofnativecorticalexcitability AT hubertdinse brainactivationinmotorsequencelearningisrelatedtothelevelofnativecorticalexcitability AT martintegenthoff brainactivationinmotorsequencelearningisrelatedtothelevelofnativecorticalexcitability
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Brain activation in motor sequence learning is related to the level of native cortical excitability.

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