Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathway.

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Autores principales:	Song Ho Chang, Daisuke Mori, Hiroshi Kobayashi, Yoshifumi Mori, Hideki Nakamoto, Keita Okada, Yuki Taniguchi, Shurei Sugita, Fumiko Yano, Ung-il Chung, Joo-ri Kim-Kaneyama, Motoko Yanagita, Aris Economides, Ernesto Canalis, Di Chen, Sakae Tanaka, Taku Saito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89ba19c2f9a9477294c478b865fc68cf
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spelling	oai:doaj.org-article:89ba19c2f9a9477294c478b865fc68cf2021-12-02T17:02:07ZExcessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway10.1038/s41467-019-09491-52041-1723https://doaj.org/article/89ba19c2f9a9477294c478b865fc68cf2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09491-5https://doaj.org/toc/2041-1723Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathway.Song Ho ChangDaisuke MoriHiroshi KobayashiYoshifumi MoriHideki NakamotoKeita OkadaYuki TaniguchiShurei SugitaFumiko YanoUng-il ChungJoo-ri Kim-KaneyamaMotoko YanagitaAris EconomidesErnesto CanalisDi ChenSakae TanakaTaku SaitoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Song Ho Chang Daisuke Mori Hiroshi Kobayashi Yoshifumi Mori Hideki Nakamoto Keita Okada Yuki Taniguchi Shurei Sugita Fumiko Yano Ung-il Chung Joo-ri Kim-Kaneyama Motoko Yanagita Aris Economides Ernesto Canalis Di Chen Sakae Tanaka Taku Saito Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
description	Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathway.
format	article
author	Song Ho Chang Daisuke Mori Hiroshi Kobayashi Yoshifumi Mori Hideki Nakamoto Keita Okada Yuki Taniguchi Shurei Sugita Fumiko Yano Ung-il Chung Joo-ri Kim-Kaneyama Motoko Yanagita Aris Economides Ernesto Canalis Di Chen Sakae Tanaka Taku Saito
author_facet	Song Ho Chang Daisuke Mori Hiroshi Kobayashi Yoshifumi Mori Hideki Nakamoto Keita Okada Yuki Taniguchi Shurei Sugita Fumiko Yano Ung-il Chung Joo-ri Kim-Kaneyama Motoko Yanagita Aris Economides Ernesto Canalis Di Chen Sakae Tanaka Taku Saito
author_sort	Song Ho Chang
title	Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
title_short	Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
title_full	Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
title_fullStr	Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
title_full_unstemmed	Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
title_sort	excessive mechanical loading promotes osteoarthritis through the gremlin-1–nf-κb pathway
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/89ba19c2f9a9477294c478b865fc68cf
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Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

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