Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathway.

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Bibliographic Details
Main Authors: Song Ho Chang, Daisuke Mori, Hiroshi Kobayashi, Yoshifumi Mori, Hideki Nakamoto, Keita Okada, Yuki Taniguchi, Shurei Sugita, Fumiko Yano, Ung-il Chung, Joo-ri Kim-Kaneyama, Motoko Yanagita, Aris Economides, Ernesto Canalis, Di Chen, Sakae Tanaka, Taku Saito
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/89ba19c2f9a9477294c478b865fc68cf
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https://doaj.org/article/89ba19c2f9a9477294c478b865fc68cf

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