COMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS

The article contains results concerning combination frequency analysis for a wide number of three- to six-locus constellations of cytokine gene alleles, i.e., IL-1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL-4 C-590T, IL-10 C-592A. The study was performed in a group of 104 patient...

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Autores principales:	V. I. Konenkov, V. F. Prokof’ev, A. V. Shevchenko, O. V. Golovanova, E. V. Zonova, M. A. Korolev, J. B. Leonova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	rheumatoid arthritis treatment efficiency cytokines gene polymorphism prediction Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/89bb435fab0443c794221e0b4a686f94
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spelling	oai:doaj.org-article:89bb435fab0443c794221e0b4a686f942021-11-18T08:03:38ZCOMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2010-4-5-361-374https://doaj.org/article/89bb435fab0443c794221e0b4a686f942014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/185https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe article contains results concerning combination frequency analysis for a wide number of three- to six-locus constellations of cytokine gene alleles, i.e., IL-1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL-4 C-590T, IL-10 C-592A. The study was performed in a group of 104 patients with rheumatoid arthritis (RA) who were subject to basic therapy with methotrexate. An association was found between certain individual multi-locus allele combinations, and efficiency of the therapy, as defined by decrease in DAS28 index following 24 week of methotrexate treatment. An association was demonstrated between adverse effects of drugs used, and a "cytokine genotype" of the patients. Analysis of the results was carried out with respect to correlations between the levels of pro- and anti-inflammatory cytokine production and promoter polymorphisms of respective genes. We assume that further clinical research will allow to use our results as pharmacogenetic criteria in order to choose more effective personalized therapies, taking into account the genotypes of RA patients.V. I. KonenkovV. F. Prokof’evA. V. ShevchenkoO. V. GolovanovaE. V. ZonovaM. A. KorolevJ. B. LeonovaSPb RAACIarticlerheumatoid arthritistreatment efficiencycytokinesgene polymorphismpredictionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 361-374 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	rheumatoid arthritis treatment efficiency cytokines gene polymorphism prediction Immunologic diseases. Allergy RC581-607
spellingShingle	rheumatoid arthritis treatment efficiency cytokines gene polymorphism prediction Immunologic diseases. Allergy RC581-607 V. I. Konenkov V. F. Prokof’ev A. V. Shevchenko O. V. Golovanova E. V. Zonova M. A. Korolev J. B. Leonova COMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS
description	The article contains results concerning combination frequency analysis for a wide number of three- to six-locus constellations of cytokine gene alleles, i.e., IL-1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL-4 C-590T, IL-10 C-592A. The study was performed in a group of 104 patients with rheumatoid arthritis (RA) who were subject to basic therapy with methotrexate. An association was found between certain individual multi-locus allele combinations, and efficiency of the therapy, as defined by decrease in DAS28 index following 24 week of methotrexate treatment. An association was demonstrated between adverse effects of drugs used, and a "cytokine genotype" of the patients. Analysis of the results was carried out with respect to correlations between the levels of pro- and anti-inflammatory cytokine production and promoter polymorphisms of respective genes. We assume that further clinical research will allow to use our results as pharmacogenetic criteria in order to choose more effective personalized therapies, taking into account the genotypes of RA patients.
format	article
author	V. I. Konenkov V. F. Prokof’ev A. V. Shevchenko O. V. Golovanova E. V. Zonova M. A. Korolev J. B. Leonova
author_facet	V. I. Konenkov V. F. Prokof’ev A. V. Shevchenko O. V. Golovanova E. V. Zonova M. A. Korolev J. B. Leonova
author_sort	V. I. Konenkov
title	COMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS
title_short	COMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS
title_full	COMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS
title_fullStr	COMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS
title_full_unstemmed	COMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS
title_sort	combination analysis of cytokine gene promoter polymorphisms of il1b t-31c, il-6 g-174c, tnfa g-238a, tnfa g-308a, tnfa c-863a, il4 c-590t, il-10 c-592a for prediction of treatment efficiency in rheumatoid arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/89bb435fab0443c794221e0b4a686f94
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COMBINATION ANALYSIS OF CYTOKINE GENE PROMOTER POLYMORPHISMS OF IL1B T-31C, IL-6 G-174C, TNFA G-238A, TNFA G-308A, TNFA C-863A, IL4 C-590T, IL-10 C-592A FOR PREDICTION OF TREATMENT EFFICIENCY IN RHEUMATOID ARTHRITIS

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