Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I

Respiratory complex I plays a key role in energy metabolism. Cryo-EM structure of a mutant accessory subunit LYRM6 from the yeast Yarrowia lipolytica and molecular dynamics simulations reveal conformational changes at the interface between LYRM6 and subunit ND3, propagated further into the complex....

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Autores principales:	Etienne Galemou Yoga, Kristian Parey, Amina Djurabekova, Outi Haapanen, Karin Siegmund, Klaus Zwicker, Vivek Sharma, Volker Zickermann, Heike Angerer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89bb52ee11ed43a19deeb0190964dfe0
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spelling	oai:doaj.org-article:89bb52ee11ed43a19deeb0190964dfe02021-12-02T16:49:28ZEssential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I10.1038/s41467-020-19778-72041-1723https://doaj.org/article/89bb52ee11ed43a19deeb0190964dfe02020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19778-7https://doaj.org/toc/2041-1723Respiratory complex I plays a key role in energy metabolism. Cryo-EM structure of a mutant accessory subunit LYRM6 from the yeast Yarrowia lipolytica and molecular dynamics simulations reveal conformational changes at the interface between LYRM6 and subunit ND3, propagated further into the complex. These findings offer insight into the mechanism of proton pumping by respiratory complex I.Etienne Galemou YogaKristian PareyAmina DjurabekovaOuti HaapanenKarin SiegmundKlaus ZwickerVivek SharmaVolker ZickermannHeike AngererNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Etienne Galemou Yoga Kristian Parey Amina Djurabekova Outi Haapanen Karin Siegmund Klaus Zwicker Vivek Sharma Volker Zickermann Heike Angerer Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
description	Respiratory complex I plays a key role in energy metabolism. Cryo-EM structure of a mutant accessory subunit LYRM6 from the yeast Yarrowia lipolytica and molecular dynamics simulations reveal conformational changes at the interface between LYRM6 and subunit ND3, propagated further into the complex. These findings offer insight into the mechanism of proton pumping by respiratory complex I.
format	article
author	Etienne Galemou Yoga Kristian Parey Amina Djurabekova Outi Haapanen Karin Siegmund Klaus Zwicker Vivek Sharma Volker Zickermann Heike Angerer
author_facet	Etienne Galemou Yoga Kristian Parey Amina Djurabekova Outi Haapanen Karin Siegmund Klaus Zwicker Vivek Sharma Volker Zickermann Heike Angerer
author_sort	Etienne Galemou Yoga
title	Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
title_short	Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
title_full	Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
title_fullStr	Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
title_full_unstemmed	Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
title_sort	essential role of accessory subunit lyrm6 in the mechanism of mitochondrial complex i
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/89bb52ee11ed43a19deeb0190964dfe0
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Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I

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