A minimal biochemical route towards de novo formation of synthetic phospholipid membranes
The origin of phospholipids, the primary constituents of cell membranes, is uncertain. Here, the authors develop an in vitro system to synthesize phospholipid molecules from water-soluble single-chain amphiphilic precursors via a reaction catalysed by the mycobacterial ligase FadD10.
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2019
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oai:doaj.org-article:89bca9b9c80c40c190a8c51af0b8b13d2021-12-02T16:57:21ZA minimal biochemical route towards de novo formation of synthetic phospholipid membranes10.1038/s41467-018-08174-x2041-1723https://doaj.org/article/89bca9b9c80c40c190a8c51af0b8b13d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08174-xhttps://doaj.org/toc/2041-1723The origin of phospholipids, the primary constituents of cell membranes, is uncertain. Here, the authors develop an in vitro system to synthesize phospholipid molecules from water-soluble single-chain amphiphilic precursors via a reaction catalysed by the mycobacterial ligase FadD10.Ahanjit BhattacharyaRoberto J. BreaHenrike NiederholtmeyerNeal K. DevarajNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019) |
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Science Q Ahanjit Bhattacharya Roberto J. Brea Henrike Niederholtmeyer Neal K. Devaraj A minimal biochemical route towards de novo formation of synthetic phospholipid membranes |
description |
The origin of phospholipids, the primary constituents of cell membranes, is uncertain. Here, the authors develop an in vitro system to synthesize phospholipid molecules from water-soluble single-chain amphiphilic precursors via a reaction catalysed by the mycobacterial ligase FadD10. |
format |
article |
author |
Ahanjit Bhattacharya Roberto J. Brea Henrike Niederholtmeyer Neal K. Devaraj |
author_facet |
Ahanjit Bhattacharya Roberto J. Brea Henrike Niederholtmeyer Neal K. Devaraj |
author_sort |
Ahanjit Bhattacharya |
title |
A minimal biochemical route towards de novo formation of synthetic phospholipid membranes |
title_short |
A minimal biochemical route towards de novo formation of synthetic phospholipid membranes |
title_full |
A minimal biochemical route towards de novo formation of synthetic phospholipid membranes |
title_fullStr |
A minimal biochemical route towards de novo formation of synthetic phospholipid membranes |
title_full_unstemmed |
A minimal biochemical route towards de novo formation of synthetic phospholipid membranes |
title_sort |
minimal biochemical route towards de novo formation of synthetic phospholipid membranes |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/89bca9b9c80c40c190a8c51af0b8b13d |
work_keys_str_mv |
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1718382577824301056 |