Developmental environment shapes honeybee worker response to virus infection

Abstract The consequences of early-life experiences are far reaching. In particular, the social and nutritional environments that developing animals experience can shape their adult phenotypes. In honeybees, larval nutrition determines the eventual social roles of adults as reproductive queens or st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexander Walton, Amy L. Toth, Adam G. Dolezal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89bd0797aca54d1d8e909811b8c4a37c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:89bd0797aca54d1d8e909811b8c4a37c
record_format	dspace
spelling	oai:doaj.org-article:89bd0797aca54d1d8e909811b8c4a37c2021-12-02T15:22:57ZDevelopmental environment shapes honeybee worker response to virus infection10.1038/s41598-021-93199-42045-2322https://doaj.org/article/89bd0797aca54d1d8e909811b8c4a37c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93199-4https://doaj.org/toc/2045-2322Abstract The consequences of early-life experiences are far reaching. In particular, the social and nutritional environments that developing animals experience can shape their adult phenotypes. In honeybees, larval nutrition determines the eventual social roles of adults as reproductive queens or sterile workers. However, little is known about the effects of developmental nutrition on important adult worker phenotypes such as disease resilience. In this study, we manipulated worker developmental nutrition in two distinct ways under semi-natural field conditions. In the first experiment, we restricted access to nutrition via social isolation by temporarily preventing alloparental care. In the second experiment, we altered the diet quality experienced by the entire colony, leading to adult bees that had developed entirely in a nutritionally restricted environment. When bees from these two experiments reached the adult stage, we challenged them with a common bee virus, Israeli acute paralysis virus (IAPV) and compared mortality, body condition, and the expression of immune genes across diet and viral inoculation treatments. Our findings show that both forms of early life nutritional stress, whether induced by lack of alloparental care or diet quality restriction, significantly reduced bees’ resilience to virus infection and affected the expression of several key genes related to immune function. These results extend our understanding of how early life nutritional environment can affect phenotypes relevant to health and highlight the importance of considering how nutritional stress can be profound even when filtered through a social group. These results also provide important insights into how nutritional stress can affect honeybee health on a longer time scale and its potential to interact with other forms of stress (i.e. disease).Alexander WaltonAmy L. TothAdam G. DolezalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Walton Amy L. Toth Adam G. Dolezal Developmental environment shapes honeybee worker response to virus infection
description	Abstract The consequences of early-life experiences are far reaching. In particular, the social and nutritional environments that developing animals experience can shape their adult phenotypes. In honeybees, larval nutrition determines the eventual social roles of adults as reproductive queens or sterile workers. However, little is known about the effects of developmental nutrition on important adult worker phenotypes such as disease resilience. In this study, we manipulated worker developmental nutrition in two distinct ways under semi-natural field conditions. In the first experiment, we restricted access to nutrition via social isolation by temporarily preventing alloparental care. In the second experiment, we altered the diet quality experienced by the entire colony, leading to adult bees that had developed entirely in a nutritionally restricted environment. When bees from these two experiments reached the adult stage, we challenged them with a common bee virus, Israeli acute paralysis virus (IAPV) and compared mortality, body condition, and the expression of immune genes across diet and viral inoculation treatments. Our findings show that both forms of early life nutritional stress, whether induced by lack of alloparental care or diet quality restriction, significantly reduced bees’ resilience to virus infection and affected the expression of several key genes related to immune function. These results extend our understanding of how early life nutritional environment can affect phenotypes relevant to health and highlight the importance of considering how nutritional stress can be profound even when filtered through a social group. These results also provide important insights into how nutritional stress can affect honeybee health on a longer time scale and its potential to interact with other forms of stress (i.e. disease).
format	article
author	Alexander Walton Amy L. Toth Adam G. Dolezal
author_facet	Alexander Walton Amy L. Toth Adam G. Dolezal
author_sort	Alexander Walton
title	Developmental environment shapes honeybee worker response to virus infection
title_short	Developmental environment shapes honeybee worker response to virus infection
title_full	Developmental environment shapes honeybee worker response to virus infection
title_fullStr	Developmental environment shapes honeybee worker response to virus infection
title_full_unstemmed	Developmental environment shapes honeybee worker response to virus infection
title_sort	developmental environment shapes honeybee worker response to virus infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/89bd0797aca54d1d8e909811b8c4a37c
work_keys_str_mv	AT alexanderwalton developmentalenvironmentshapeshoneybeeworkerresponsetovirusinfection AT amyltoth developmentalenvironmentshapeshoneybeeworkerresponsetovirusinfection AT adamgdolezal developmentalenvironmentshapeshoneybeeworkerresponsetovirusinfection
_version_	1718387390460985344

Developmental environment shapes honeybee worker response to virus infection

Ejemplares similares