Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies

The apolipoprotein E (APOE) gene contains both the major common risk variant associated with clinically diagnosed late onset Alzheimer’s disease (AD), APOE e4, and a neuroprotective variant, APOE e2. Here the authors confirm that the e2 allele is protective against Alzheimer’s disease neuropathologi...

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Autores principales:	Terry E. Goldberg, Edward D. Huey, D. P. Devanand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89c17b36a56344e28c62aeac01d317cd
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spelling	oai:doaj.org-article:89c17b36a56344e28c62aeac01d317cd2021-12-02T15:16:10ZAssociation of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies10.1038/s41467-020-18198-x2041-1723https://doaj.org/article/89c17b36a56344e28c62aeac01d317cd2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18198-xhttps://doaj.org/toc/2041-1723The apolipoprotein E (APOE) gene contains both the major common risk variant associated with clinically diagnosed late onset Alzheimer’s disease (AD), APOE e4, and a neuroprotective variant, APOE e2. Here the authors confirm that the e2 allele is protective against Alzheimer’s disease neuropathologies, but show that it is not protective against other neurodegenerative disorders.Terry E. GoldbergEdward D. HueyD. P. DevanandNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Terry E. Goldberg Edward D. Huey D. P. Devanand Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
description	The apolipoprotein E (APOE) gene contains both the major common risk variant associated with clinically diagnosed late onset Alzheimer’s disease (AD), APOE e4, and a neuroprotective variant, APOE e2. Here the authors confirm that the e2 allele is protective against Alzheimer’s disease neuropathologies, but show that it is not protective against other neurodegenerative disorders.
format	article
author	Terry E. Goldberg Edward D. Huey D. P. Devanand
author_facet	Terry E. Goldberg Edward D. Huey D. P. Devanand
author_sort	Terry E. Goldberg
title	Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
title_short	Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
title_full	Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
title_fullStr	Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
title_full_unstemmed	Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
title_sort	association of apoe e2 genotype with alzheimer’s and non-alzheimer’s neurodegenerative pathologies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/89c17b36a56344e28c62aeac01d317cd
work_keys_str_mv	AT terryegoldberg associationofapoee2genotypewithalzheimersandnonalzheimersneurodegenerativepathologies AT edwarddhuey associationofapoee2genotypewithalzheimersandnonalzheimersneurodegenerativepathologies AT dpdevanand associationofapoee2genotypewithalzheimersandnonalzheimersneurodegenerativepathologies
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Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies

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