Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

Objective: Ischemic stroke is an important cause of death and disability worldwide. Early reperfusion by thrombolysis or thrombectomy has improved the outcome of acute ischemic stroke. However, the therapeutic window for reperfusion therapy is narrow, and adjuvant therapy for neuroprotection is dema...

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Autores principales:	Liang-Chao Wang, Wei-Yen Wei, Pei-Chuan Ho, Pei-Yi Wu, Yuan-Ping Chu, Kuen-Jer Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cortical electrical stimulation neuromodulation ischemic stroke BDNF PI3K – PKB/Akt signaling pathway Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/89c18733ec784a6dad1c8fc159604ea3
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spelling	oai:doaj.org-article:89c18733ec784a6dad1c8fc159604ea32021-11-12T04:49:21ZSomatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain1663-436510.3389/fnagi.2021.741168https://doaj.org/article/89c18733ec784a6dad1c8fc159604ea32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.741168/fullhttps://doaj.org/toc/1663-4365Objective: Ischemic stroke is an important cause of death and disability worldwide. Early reperfusion by thrombolysis or thrombectomy has improved the outcome of acute ischemic stroke. However, the therapeutic window for reperfusion therapy is narrow, and adjuvant therapy for neuroprotection is demanded. Electrical stimulation (ES) has been reported to be neuroprotective in many neurological diseases. In this study, the neuroprotective effect of early somatosensory cortical ES in the acute stage of ischemia/reperfusion injury was evaluated.Methods: In this study, the rat model of transient middle cerebral artery occlusion was used to explore the neuroprotective effect and underlying mechanisms of direct primary somatosensory (S1) cortex ES with an electric current of 20 Hz, 2 ms biphasic pulse, 100 μA for 30 min, starting at 30 min after reperfusion.Results: These results showed that S1 cortical ES after reperfusion decreased infarction volume and improved functional outcome. The number of activated microglia, astrocytes, and cleaved caspase-3 positive neurons after ischemia/reperfusion injury were reduced, demonstrating that S1 cortical ES alleviates inflammation and apoptosis. Brain-derived neurotrophic factor (BDNF) and phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway were upregulated in the penumbra area, suggesting that BDNF/TrkB signals and their downstream PI3K/Akt signaling pathway play roles in ES-related neuroprotection.Conclusion: This study demonstrates that somatosensory cortical ES soon after reperfusion can attenuate ischemia/reperfusion injury and is a promising adjuvant therapy for thrombolytic treatment after acute ischemic stroke. Advanced techniques and devices for high-definition transcranial direct current stimulation still deserve further development in this regard.Liang-Chao WangLiang-Chao WangWei-Yen WeiPei-Chuan HoPei-Yi WuYuan-Ping ChuKuen-Jer TsaiKuen-Jer TsaiKuen-Jer TsaiFrontiers Media S.A.articlecortical electrical stimulationneuromodulationischemic strokeBDNFPI3K – PKB/Akt signaling pathwayNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cortical electrical stimulation neuromodulation ischemic stroke BDNF PI3K – PKB/Akt signaling pathway Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	cortical electrical stimulation neuromodulation ischemic stroke BDNF PI3K – PKB/Akt signaling pathway Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Liang-Chao Wang Liang-Chao Wang Wei-Yen Wei Pei-Chuan Ho Pei-Yi Wu Yuan-Ping Chu Kuen-Jer Tsai Kuen-Jer Tsai Kuen-Jer Tsai Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain
description	Objective: Ischemic stroke is an important cause of death and disability worldwide. Early reperfusion by thrombolysis or thrombectomy has improved the outcome of acute ischemic stroke. However, the therapeutic window for reperfusion therapy is narrow, and adjuvant therapy for neuroprotection is demanded. Electrical stimulation (ES) has been reported to be neuroprotective in many neurological diseases. In this study, the neuroprotective effect of early somatosensory cortical ES in the acute stage of ischemia/reperfusion injury was evaluated.Methods: In this study, the rat model of transient middle cerebral artery occlusion was used to explore the neuroprotective effect and underlying mechanisms of direct primary somatosensory (S1) cortex ES with an electric current of 20 Hz, 2 ms biphasic pulse, 100 μA for 30 min, starting at 30 min after reperfusion.Results: These results showed that S1 cortical ES after reperfusion decreased infarction volume and improved functional outcome. The number of activated microglia, astrocytes, and cleaved caspase-3 positive neurons after ischemia/reperfusion injury were reduced, demonstrating that S1 cortical ES alleviates inflammation and apoptosis. Brain-derived neurotrophic factor (BDNF) and phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway were upregulated in the penumbra area, suggesting that BDNF/TrkB signals and their downstream PI3K/Akt signaling pathway play roles in ES-related neuroprotection.Conclusion: This study demonstrates that somatosensory cortical ES soon after reperfusion can attenuate ischemia/reperfusion injury and is a promising adjuvant therapy for thrombolytic treatment after acute ischemic stroke. Advanced techniques and devices for high-definition transcranial direct current stimulation still deserve further development in this regard.
format	article
author	Liang-Chao Wang Liang-Chao Wang Wei-Yen Wei Pei-Chuan Ho Pei-Yi Wu Yuan-Ping Chu Kuen-Jer Tsai Kuen-Jer Tsai Kuen-Jer Tsai
author_facet	Liang-Chao Wang Liang-Chao Wang Wei-Yen Wei Pei-Chuan Ho Pei-Yi Wu Yuan-Ping Chu Kuen-Jer Tsai Kuen-Jer Tsai Kuen-Jer Tsai
author_sort	Liang-Chao Wang
title	Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain
title_short	Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain
title_full	Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain
title_fullStr	Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain
title_full_unstemmed	Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain
title_sort	somatosensory cortical electrical stimulation after reperfusion attenuates ischemia/reperfusion injury of rat brain
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/89c18733ec784a6dad1c8fc159604ea3
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Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

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