Host defense against oral microbiota by bone-damaging T cells

IL-17-producing T cells are protective against infection, but the authors of this article previously showed that these cells also contribute to inflammatory bone destruction. Here they show in the context of periodontitis that microbiota-driven Th17-mediated bone destruction may actually be a physio...

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Autores principales:	Masayuki Tsukasaki, Noriko Komatsu, Kazuki Nagashima, Takeshi Nitta, Warunee Pluemsakunthai, Chisa Shukunami, Yoichiro Iwakura, Tomoki Nakashima, Kazuo Okamoto, Hiroshi Takayanagi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89c1ce4662c546e1b7232d546be96290
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spelling	oai:doaj.org-article:89c1ce4662c546e1b7232d546be962902021-12-02T16:56:58ZHost defense against oral microbiota by bone-damaging T cells10.1038/s41467-018-03147-62041-1723https://doaj.org/article/89c1ce4662c546e1b7232d546be962902018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03147-6https://doaj.org/toc/2041-1723IL-17-producing T cells are protective against infection, but the authors of this article previously showed that these cells also contribute to inflammatory bone destruction. Here they show in the context of periodontitis that microbiota-driven Th17-mediated bone destruction may actually be a physiological rather than a pathological process, as associated tooth loss prevents dissemination of oral bacteria.Masayuki TsukasakiNoriko KomatsuKazuki NagashimaTakeshi NittaWarunee PluemsakunthaiChisa ShukunamiYoichiro IwakuraTomoki NakashimaKazuo OkamotoHiroshi TakayanagiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masayuki Tsukasaki Noriko Komatsu Kazuki Nagashima Takeshi Nitta Warunee Pluemsakunthai Chisa Shukunami Yoichiro Iwakura Tomoki Nakashima Kazuo Okamoto Hiroshi Takayanagi Host defense against oral microbiota by bone-damaging T cells
description	IL-17-producing T cells are protective against infection, but the authors of this article previously showed that these cells also contribute to inflammatory bone destruction. Here they show in the context of periodontitis that microbiota-driven Th17-mediated bone destruction may actually be a physiological rather than a pathological process, as associated tooth loss prevents dissemination of oral bacteria.
format	article
author	Masayuki Tsukasaki Noriko Komatsu Kazuki Nagashima Takeshi Nitta Warunee Pluemsakunthai Chisa Shukunami Yoichiro Iwakura Tomoki Nakashima Kazuo Okamoto Hiroshi Takayanagi
author_facet	Masayuki Tsukasaki Noriko Komatsu Kazuki Nagashima Takeshi Nitta Warunee Pluemsakunthai Chisa Shukunami Yoichiro Iwakura Tomoki Nakashima Kazuo Okamoto Hiroshi Takayanagi
author_sort	Masayuki Tsukasaki
title	Host defense against oral microbiota by bone-damaging T cells
title_short	Host defense against oral microbiota by bone-damaging T cells
title_full	Host defense against oral microbiota by bone-damaging T cells
title_fullStr	Host defense against oral microbiota by bone-damaging T cells
title_full_unstemmed	Host defense against oral microbiota by bone-damaging T cells
title_sort	host defense against oral microbiota by bone-damaging t cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/89c1ce4662c546e1b7232d546be96290
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Host defense against oral microbiota by bone-damaging T cells

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