ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

The ubiquitin-like modifier ISG15 exerts post-translational protein regulation through ISGylation. Here, the authors show that ISGylation is necessary for pancreatic cancer stem cell self-renewal and tumourigenesis by supporting the recycling of non-functional mitochondria.

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Detalles Bibliográficos
Autores principales:	Sonia Alcalá, Patricia Sancho, Paola Martinelli, Diego Navarro, Coral Pedrero, Laura Martín-Hijano, Sandra Valle, Julie Earl, Macarena Rodríguez-Serrano, Laura Ruiz-Cañas, Katerin Rojas, Alfredo Carrato, Laura García-Bermejo, Miguel Ángel Fernández-Moreno, Patrick C. Hermann, Bruno Sainz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89c3ab82d8814e75bb09a84a79555d89
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spelling	oai:doaj.org-article:89c3ab82d8814e75bb09a84a79555d892021-12-02T15:49:34ZISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity10.1038/s41467-020-16395-22041-1723https://doaj.org/article/89c3ab82d8814e75bb09a84a79555d892020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16395-2https://doaj.org/toc/2041-1723The ubiquitin-like modifier ISG15 exerts post-translational protein regulation through ISGylation. Here, the authors show that ISGylation is necessary for pancreatic cancer stem cell self-renewal and tumourigenesis by supporting the recycling of non-functional mitochondria.Sonia AlcaláPatricia SanchoPaola MartinelliDiego NavarroCoral PedreroLaura Martín-HijanoSandra ValleJulie EarlMacarena Rodríguez-SerranoLaura Ruiz-CañasKaterin RojasAlfredo CarratoLaura García-BermejoMiguel Ángel Fernández-MorenoPatrick C. HermannBruno SainzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sonia Alcalá Patricia Sancho Paola Martinelli Diego Navarro Coral Pedrero Laura Martín-Hijano Sandra Valle Julie Earl Macarena Rodríguez-Serrano Laura Ruiz-Cañas Katerin Rojas Alfredo Carrato Laura García-Bermejo Miguel Ángel Fernández-Moreno Patrick C. Hermann Bruno Sainz ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
description	The ubiquitin-like modifier ISG15 exerts post-translational protein regulation through ISGylation. Here, the authors show that ISGylation is necessary for pancreatic cancer stem cell self-renewal and tumourigenesis by supporting the recycling of non-functional mitochondria.
format	article
author	Sonia Alcalá Patricia Sancho Paola Martinelli Diego Navarro Coral Pedrero Laura Martín-Hijano Sandra Valle Julie Earl Macarena Rodríguez-Serrano Laura Ruiz-Cañas Katerin Rojas Alfredo Carrato Laura García-Bermejo Miguel Ángel Fernández-Moreno Patrick C. Hermann Bruno Sainz
author_facet	Sonia Alcalá Patricia Sancho Paola Martinelli Diego Navarro Coral Pedrero Laura Martín-Hijano Sandra Valle Julie Earl Macarena Rodríguez-Serrano Laura Ruiz-Cañas Katerin Rojas Alfredo Carrato Laura García-Bermejo Miguel Ángel Fernández-Moreno Patrick C. Hermann Bruno Sainz
author_sort	Sonia Alcalá
title	ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
title_short	ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
title_full	ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
title_fullStr	ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
title_full_unstemmed	ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
title_sort	isg15 and isgylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/89c3ab82d8814e75bb09a84a79555d89
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ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

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