PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients

Abstract To identify the risk factors of mortality for the coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICUs) through a retrospective analysis. The demographic, clinical, laboratory, and chest imaging data of patients admitted to the ICU of Huoshenshan Hospital from F...

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Autores principales:	Yanli Gu, Donghui Wang, Cen Chen, Wanjun Lu, Hongbing Liu, Tangfeng Lv, Yong Song, Fang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89c5ebe5c96b4db28f53f0c7d4b3fb7b
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spelling	oai:doaj.org-article:89c5ebe5c96b4db28f53f0c7d4b3fb7b2021-12-02T13:26:58ZPaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients10.1038/s41598-021-86676-32045-2322https://doaj.org/article/89c5ebe5c96b4db28f53f0c7d4b3fb7b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86676-3https://doaj.org/toc/2045-2322Abstract To identify the risk factors of mortality for the coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICUs) through a retrospective analysis. The demographic, clinical, laboratory, and chest imaging data of patients admitted to the ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t-test and Chi-square test were used to compare the continuous and categorical variables, respectively. The logistic regression model was employed to ascertain the risk factors of mortality. This retrospective study involved 123 patients, including 64 dead and 59 survivors. Among them, 57 people were tested for interleukin-6 (IL-6) (20 died and 37 survived). In all included patients, the oxygenation index (PaO2/FiO2) was identified as an independent risk factor (odd ratio [OR] = 0.96, 95% confidence interval [CI]: 0.928–0.994, p = 0.021). The area under the curve (AUC) was 0.895 (95% CI: 0.826–0.943, p < 0.0001). Among the patients tested for IL-6, the PaO2/FiO2 (OR = 0.955, 95%CI: 0.915–0.996, p = 0.032) and IL-6 (OR = 1.013, 95%CI: 1.001–1.025, p = 0.028) were identified as independent risk factors. The AUC was 0.9 (95% CI: 0.791–0.964, p < 0.0001) for IL-6 and 0.865 (95% CI: 0.748–0.941, p < 0.0001) for PaO2/FiO2. PaO2/FiO2 and IL-6 could potentially serve as independent risk factors for predicting death in COVID-19 patients requiring intensive care.Yanli GuDonghui WangCen ChenWanjun LuHongbing LiuTangfeng LvYong SongFang ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanli Gu Donghui Wang Cen Chen Wanjun Lu Hongbing Liu Tangfeng Lv Yong Song Fang Zhang PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients
description	Abstract To identify the risk factors of mortality for the coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICUs) through a retrospective analysis. The demographic, clinical, laboratory, and chest imaging data of patients admitted to the ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t-test and Chi-square test were used to compare the continuous and categorical variables, respectively. The logistic regression model was employed to ascertain the risk factors of mortality. This retrospective study involved 123 patients, including 64 dead and 59 survivors. Among them, 57 people were tested for interleukin-6 (IL-6) (20 died and 37 survived). In all included patients, the oxygenation index (PaO2/FiO2) was identified as an independent risk factor (odd ratio [OR] = 0.96, 95% confidence interval [CI]: 0.928–0.994, p = 0.021). The area under the curve (AUC) was 0.895 (95% CI: 0.826–0.943, p < 0.0001). Among the patients tested for IL-6, the PaO2/FiO2 (OR = 0.955, 95%CI: 0.915–0.996, p = 0.032) and IL-6 (OR = 1.013, 95%CI: 1.001–1.025, p = 0.028) were identified as independent risk factors. The AUC was 0.9 (95% CI: 0.791–0.964, p < 0.0001) for IL-6 and 0.865 (95% CI: 0.748–0.941, p < 0.0001) for PaO2/FiO2. PaO2/FiO2 and IL-6 could potentially serve as independent risk factors for predicting death in COVID-19 patients requiring intensive care.
format	article
author	Yanli Gu Donghui Wang Cen Chen Wanjun Lu Hongbing Liu Tangfeng Lv Yong Song Fang Zhang
author_facet	Yanli Gu Donghui Wang Cen Chen Wanjun Lu Hongbing Liu Tangfeng Lv Yong Song Fang Zhang
author_sort	Yanli Gu
title	PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients
title_short	PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients
title_full	PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients
title_fullStr	PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients
title_full_unstemmed	PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients
title_sort	pao2/fio2 and il-6 are risk factors of mortality for intensive care covid-19 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/89c5ebe5c96b4db28f53f0c7d4b3fb7b
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PaO2/FiO2 and IL-6 are risk factors of mortality for intensive care COVID-19 patients

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