PRDM12 in Health and Diseases

PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1) homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc finger proteins, controlling key processes in the development of cancer. <i>PRDM12</i> is expressed in a spatio-temporal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Monica Rienzo, Erika Di Zazzo, Amelia Casamassimi, Patrizia Gazzerro, Giovanni Perini, Maurizio Bifulco, Ciro Abbondanza
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer cell metabolism neurogenesis pain perception PRD-BF1 and RIZ homology domain containing gene family <i>PRDM12</i> Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/89c80b1786fe4a33b9e593fa282d71c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:89c80b1786fe4a33b9e593fa282d71c9
record_format	dspace
spelling	oai:doaj.org-article:89c80b1786fe4a33b9e593fa282d71c92021-11-11T17:25:47ZPRDM12 in Health and Diseases10.3390/ijms2221120301422-00671661-6596https://doaj.org/article/89c80b1786fe4a33b9e593fa282d71c92021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12030https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1) homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc finger proteins, controlling key processes in the development of cancer. <i>PRDM12</i> is expressed in a spatio-temporal manner in neuronal systems where it exerts multiple functions. PRDM12 is essential for the neurogenesis initiation and activation of a cascade of downstream pro-neuronal transcription factors in the nociceptive lineage. <i>PRDM12</i> inactivation, indeed, results in a complete absence of the nociceptive lineage, which is essential for pain perception. Additionally, PRDM12 contributes to the early establishment of anorexigenic neuron identity and the maintenance of high expression levels of pro-opiomelanocortin, which impacts on the program bodyweight homeostasis. PRDMs are commonly involved in cancer, where they act as oncogenes/tumor suppressors in a “Yin and Yang” manner. <i>PRDM12</i> is not usually expressed in adult normal tissues but its expression is re-activated in several cancer types. However, little information is currently available on <i>PRDM12</i> expression in cancers and its mechanism of action has not been thoroughly described. In this review, we summarize the recent findings regarding PRDM12 by focusing on four main biological processes: neurogenesis, pain perception, oncogenesis and cell metabolism. Moreover, we wish to highlight the importance of future studies focusing on the PRDM12 signaling pathway(s) and its role in cancer onset and progression.Monica RienzoErika Di ZazzoAmelia CasamassimiPatrizia GazzerroGiovanni PeriniMaurizio BifulcoCiro AbbondanzaMDPI AGarticlecancercell metabolismneurogenesispain perceptionPRD-BF1 and RIZ homology domain containing gene family<i>PRDM12</i>Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12030, p 12030 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer cell metabolism neurogenesis pain perception PRD-BF1 and RIZ homology domain containing gene family <i>PRDM12</i> Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cancer cell metabolism neurogenesis pain perception PRD-BF1 and RIZ homology domain containing gene family <i>PRDM12</i> Biology (General) QH301-705.5 Chemistry QD1-999 Monica Rienzo Erika Di Zazzo Amelia Casamassimi Patrizia Gazzerro Giovanni Perini Maurizio Bifulco Ciro Abbondanza PRDM12 in Health and Diseases
description	PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1) homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc finger proteins, controlling key processes in the development of cancer. <i>PRDM12</i> is expressed in a spatio-temporal manner in neuronal systems where it exerts multiple functions. PRDM12 is essential for the neurogenesis initiation and activation of a cascade of downstream pro-neuronal transcription factors in the nociceptive lineage. <i>PRDM12</i> inactivation, indeed, results in a complete absence of the nociceptive lineage, which is essential for pain perception. Additionally, PRDM12 contributes to the early establishment of anorexigenic neuron identity and the maintenance of high expression levels of pro-opiomelanocortin, which impacts on the program bodyweight homeostasis. PRDMs are commonly involved in cancer, where they act as oncogenes/tumor suppressors in a “Yin and Yang” manner. <i>PRDM12</i> is not usually expressed in adult normal tissues but its expression is re-activated in several cancer types. However, little information is currently available on <i>PRDM12</i> expression in cancers and its mechanism of action has not been thoroughly described. In this review, we summarize the recent findings regarding PRDM12 by focusing on four main biological processes: neurogenesis, pain perception, oncogenesis and cell metabolism. Moreover, we wish to highlight the importance of future studies focusing on the PRDM12 signaling pathway(s) and its role in cancer onset and progression.
format	article
author	Monica Rienzo Erika Di Zazzo Amelia Casamassimi Patrizia Gazzerro Giovanni Perini Maurizio Bifulco Ciro Abbondanza
author_facet	Monica Rienzo Erika Di Zazzo Amelia Casamassimi Patrizia Gazzerro Giovanni Perini Maurizio Bifulco Ciro Abbondanza
author_sort	Monica Rienzo
title	PRDM12 in Health and Diseases
title_short	PRDM12 in Health and Diseases
title_full	PRDM12 in Health and Diseases
title_fullStr	PRDM12 in Health and Diseases
title_full_unstemmed	PRDM12 in Health and Diseases
title_sort	prdm12 in health and diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/89c80b1786fe4a33b9e593fa282d71c9
work_keys_str_mv	AT monicarienzo prdm12inhealthanddiseases AT erikadizazzo prdm12inhealthanddiseases AT ameliacasamassimi prdm12inhealthanddiseases AT patriziagazzerro prdm12inhealthanddiseases AT giovanniperini prdm12inhealthanddiseases AT mauriziobifulco prdm12inhealthanddiseases AT ciroabbondanza prdm12inhealthanddiseases
_version_	1718432074795319296

PRDM12 in Health and Diseases

Ejemplares similares