Functional aspects of the Eustachian tube by means of 3D-modeling.

The extent of dysfunction of the Eustachian tube (ET) is relevant in understanding the pathogenesis of secondary otological diseases such as acute or chronic otitis media. The underlying mechanism of ET dysfunction remains poorly understood except for an apparent genesis such as a nasopharyngeal tum...

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Autores principales:	Robert Schuon, Josef Schwarzensteiner, Gerrit Paasche, Thomas Lenarz, Samuel John
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89cf4ab596cd4447ade06a37f7e67b73
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spelling	oai:doaj.org-article:89cf4ab596cd4447ade06a37f7e67b732021-12-02T20:15:03ZFunctional aspects of the Eustachian tube by means of 3D-modeling.1932-620310.1371/journal.pone.0244909https://doaj.org/article/89cf4ab596cd4447ade06a37f7e67b732021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0244909https://doaj.org/toc/1932-6203The extent of dysfunction of the Eustachian tube (ET) is relevant in understanding the pathogenesis of secondary otological diseases such as acute or chronic otitis media. The underlying mechanism of ET dysfunction remains poorly understood except for an apparent genesis such as a nasopharyngeal tumor or cleft palate. To better describe the ET, its functional anatomy, and the biomechanical valve mechanism and subsequent development of diagnostic and interventional tools, a three-dimensional model based on thin-layer histology was created from an ET in this study. Blackface sheep was chosen as a donor. The 3-D model was generated by the coherent alignment of the sections. It was then compared with the cone-beam computed tomography dataset of the complete embedded specimen taken before slicing. The model shows the topographic relation of the individual components, such as the bone and cartilage, the muscles and connective tissue, as well as the lining epithelium with the lumen. It indicates a limited spiraling rotation of the cartilaginous tube over its length and relevant positional relationships of the tensor and levator veli palatine muscles.Robert SchuonJosef SchwarzensteinerGerrit PaascheThomas LenarzSamuel JohnPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0244909 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robert Schuon Josef Schwarzensteiner Gerrit Paasche Thomas Lenarz Samuel John Functional aspects of the Eustachian tube by means of 3D-modeling.
description	The extent of dysfunction of the Eustachian tube (ET) is relevant in understanding the pathogenesis of secondary otological diseases such as acute or chronic otitis media. The underlying mechanism of ET dysfunction remains poorly understood except for an apparent genesis such as a nasopharyngeal tumor or cleft palate. To better describe the ET, its functional anatomy, and the biomechanical valve mechanism and subsequent development of diagnostic and interventional tools, a three-dimensional model based on thin-layer histology was created from an ET in this study. Blackface sheep was chosen as a donor. The 3-D model was generated by the coherent alignment of the sections. It was then compared with the cone-beam computed tomography dataset of the complete embedded specimen taken before slicing. The model shows the topographic relation of the individual components, such as the bone and cartilage, the muscles and connective tissue, as well as the lining epithelium with the lumen. It indicates a limited spiraling rotation of the cartilaginous tube over its length and relevant positional relationships of the tensor and levator veli palatine muscles.
format	article
author	Robert Schuon Josef Schwarzensteiner Gerrit Paasche Thomas Lenarz Samuel John
author_facet	Robert Schuon Josef Schwarzensteiner Gerrit Paasche Thomas Lenarz Samuel John
author_sort	Robert Schuon
title	Functional aspects of the Eustachian tube by means of 3D-modeling.
title_short	Functional aspects of the Eustachian tube by means of 3D-modeling.
title_full	Functional aspects of the Eustachian tube by means of 3D-modeling.
title_fullStr	Functional aspects of the Eustachian tube by means of 3D-modeling.
title_full_unstemmed	Functional aspects of the Eustachian tube by means of 3D-modeling.
title_sort	functional aspects of the eustachian tube by means of 3d-modeling.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/89cf4ab596cd4447ade06a37f7e67b73
work_keys_str_mv	AT robertschuon functionalaspectsoftheeustachiantubebymeansof3dmodeling AT josefschwarzensteiner functionalaspectsoftheeustachiantubebymeansof3dmodeling AT gerritpaasche functionalaspectsoftheeustachiantubebymeansof3dmodeling AT thomaslenarz functionalaspectsoftheeustachiantubebymeansof3dmodeling AT samueljohn functionalaspectsoftheeustachiantubebymeansof3dmodeling
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Functional aspects of the Eustachian tube by means of 3D-modeling.

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