Exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film

A significant rise in bone-related defects affects the quality of life which impels researchers to facilitate the new approaches for bone regeneration. Herein, we have explored the bioactive nature of nano-titania for its utilization in bone tissue engineering. The titania-doped ternary nanocomposit...

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Autores principales:	Tooba Fatima, Reshma Jolly, Mohammad Rafiq Wani, G.G.H.A. Shadab, Mohammad Shakir
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Nanocomposite film Bone regeneration Haemocompatability Reinforcement effect TiO2 nanoparticles Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/89cf5b3e7a934ab48854672d5fa3cb4e
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spelling	oai:doaj.org-article:89cf5b3e7a934ab48854672d5fa3cb4e2021-11-28T04:37:35ZExploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film2590-048X10.1016/j.rinma.2021.100240https://doaj.org/article/89cf5b3e7a934ab48854672d5fa3cb4e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590048X2100073Xhttps://doaj.org/toc/2590-048XA significant rise in bone-related defects affects the quality of life which impels researchers to facilitate the new approaches for bone regeneration. Herein, we have explored the bioactive nature of nano-titania for its utilization in bone tissue engineering. The titania-doped ternary nanocomposite film (PVA/NC-TiO2) was prepared by the fusion of Polyvinylalcohol (PVA), nano-cellulose (NC), and TiO2 (0.01 wt%) nanoparticles via sol-gel casting and compared with its binary nanocomposite film (PVA/NC). The simple and low-cost synthesis of these nanocomposite films, together with remarkable bioactive and thermo-mechanical properties, makes them a good candidate for their applications in human bone regeneration. The fabricated nanocomposite films were characterized through Fourier transform infra-red, Ultra-violet spectroscopy, and X-ray diffraction analysis to study complex formation and intermolecular interactions between the molecular entities.The SEM and TEM micrographs revealed the smooth surface of the developed binary and ternary nanocomposite films along with homogenous particle distribution. The thermo-mechanical stability was significantly improved when the nanocomposite film was modified with TiO2 nanoparticles indicating an enhancement of intermolecular interactions in PVA/NC-TiO2 film as compared to PVA/NC film. The Dynamic mechanical analysis results show higher storage modulus and glass transition temperature for PVA/NC-TiO2 film (9131.26 MPa, 74.3 °C) than PVA/NC film (7588 MPa, 64.3 °C). A comparative analysis of nanocomposite films revealed that PVA/NC-TiO2 film exhibited a thick and more uniformed layer of Ca–P mineral on its surface than PVA/NC film when incubated in Simulated Buffer Saline. The low loading of TiO2 nanoparticles resulted in a positive reinforcement effect on the bioactivity of the PVA/NC-TiO2 film (cell viability higher than 80%, hemolysis less than 1.7%) which provides an effective gateway for polymer nanocomposites in the dynamic orthopedic application by serving a better bone template for the regeneration of bone tissue.Tooba FatimaReshma JollyMohammad Rafiq WaniG.G.H.A. ShadabMohammad ShakirElsevierarticleNanocomposite filmBone regenerationHaemocompatabilityReinforcement effectTiO2 nanoparticlesMaterials of engineering and construction. Mechanics of materialsTA401-492ENResults in Materials, Vol 12, Iss , Pp 100240- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanocomposite film Bone regeneration Haemocompatability Reinforcement effect TiO2 nanoparticles Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Nanocomposite film Bone regeneration Haemocompatability Reinforcement effect TiO2 nanoparticles Materials of engineering and construction. Mechanics of materials TA401-492 Tooba Fatima Reshma Jolly Mohammad Rafiq Wani G.G.H.A. Shadab Mohammad Shakir Exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film
description	A significant rise in bone-related defects affects the quality of life which impels researchers to facilitate the new approaches for bone regeneration. Herein, we have explored the bioactive nature of nano-titania for its utilization in bone tissue engineering. The titania-doped ternary nanocomposite film (PVA/NC-TiO2) was prepared by the fusion of Polyvinylalcohol (PVA), nano-cellulose (NC), and TiO2 (0.01 wt%) nanoparticles via sol-gel casting and compared with its binary nanocomposite film (PVA/NC). The simple and low-cost synthesis of these nanocomposite films, together with remarkable bioactive and thermo-mechanical properties, makes them a good candidate for their applications in human bone regeneration. The fabricated nanocomposite films were characterized through Fourier transform infra-red, Ultra-violet spectroscopy, and X-ray diffraction analysis to study complex formation and intermolecular interactions between the molecular entities.The SEM and TEM micrographs revealed the smooth surface of the developed binary and ternary nanocomposite films along with homogenous particle distribution. The thermo-mechanical stability was significantly improved when the nanocomposite film was modified with TiO2 nanoparticles indicating an enhancement of intermolecular interactions in PVA/NC-TiO2 film as compared to PVA/NC film. The Dynamic mechanical analysis results show higher storage modulus and glass transition temperature for PVA/NC-TiO2 film (9131.26 MPa, 74.3 °C) than PVA/NC film (7588 MPa, 64.3 °C). A comparative analysis of nanocomposite films revealed that PVA/NC-TiO2 film exhibited a thick and more uniformed layer of Ca–P mineral on its surface than PVA/NC film when incubated in Simulated Buffer Saline. The low loading of TiO2 nanoparticles resulted in a positive reinforcement effect on the bioactivity of the PVA/NC-TiO2 film (cell viability higher than 80%, hemolysis less than 1.7%) which provides an effective gateway for polymer nanocomposites in the dynamic orthopedic application by serving a better bone template for the regeneration of bone tissue.
format	article
author	Tooba Fatima Reshma Jolly Mohammad Rafiq Wani G.G.H.A. Shadab Mohammad Shakir
author_facet	Tooba Fatima Reshma Jolly Mohammad Rafiq Wani G.G.H.A. Shadab Mohammad Shakir
author_sort	Tooba Fatima
title	Exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film
title_short	Exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film
title_full	Exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film
title_fullStr	Exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film
title_full_unstemmed	Exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film
title_sort	exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/89cf5b3e7a934ab48854672d5fa3cb4e
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Exploring the bone regeneration potential of bio-fabricated nano-titania reinforced polyvinyl alcohol / nano-cellulose based composite film

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