Serotonin signals through a gut-liver axis to regulate hepatic steatosis

No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or...

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Autores principales:	Wonsuk Choi, Jun Namkung, Inseon Hwang, Hyeongseok Kim, Ajin Lim, Hye Jung Park, Hye Won Lee, Kwang-Hyub Han, Seongyeol Park, Ji-Seon Jeong, Geul Bang, Young Hwan Kim, Vijay K. Yadav, Gerard Karsenty, Young Seok Ju, Chan Choi, Jae Myoung Suh, Jun Yong Park, Sangkyu Park, Hail Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89d5af7961f4435c8b79cd484b17891a
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spelling	oai:doaj.org-article:89d5af7961f4435c8b79cd484b17891a2021-12-02T16:56:52ZSerotonin signals through a gut-liver axis to regulate hepatic steatosis10.1038/s41467-018-07287-72041-1723https://doaj.org/article/89d5af7961f4435c8b79cd484b17891a2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07287-7https://doaj.org/toc/2041-1723No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or with an antagonist, prevents hepatic steatosis in mice.Wonsuk ChoiJun NamkungInseon HwangHyeongseok KimAjin LimHye Jung ParkHye Won LeeKwang-Hyub HanSeongyeol ParkJi-Seon JeongGeul BangYoung Hwan KimVijay K. YadavGerard KarsentyYoung Seok JuChan ChoiJae Myoung SuhJun Yong ParkSangkyu ParkHail KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wonsuk Choi Jun Namkung Inseon Hwang Hyeongseok Kim Ajin Lim Hye Jung Park Hye Won Lee Kwang-Hyub Han Seongyeol Park Ji-Seon Jeong Geul Bang Young Hwan Kim Vijay K. Yadav Gerard Karsenty Young Seok Ju Chan Choi Jae Myoung Suh Jun Yong Park Sangkyu Park Hail Kim Serotonin signals through a gut-liver axis to regulate hepatic steatosis
description	No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or with an antagonist, prevents hepatic steatosis in mice.
format	article
author	Wonsuk Choi Jun Namkung Inseon Hwang Hyeongseok Kim Ajin Lim Hye Jung Park Hye Won Lee Kwang-Hyub Han Seongyeol Park Ji-Seon Jeong Geul Bang Young Hwan Kim Vijay K. Yadav Gerard Karsenty Young Seok Ju Chan Choi Jae Myoung Suh Jun Yong Park Sangkyu Park Hail Kim
author_facet	Wonsuk Choi Jun Namkung Inseon Hwang Hyeongseok Kim Ajin Lim Hye Jung Park Hye Won Lee Kwang-Hyub Han Seongyeol Park Ji-Seon Jeong Geul Bang Young Hwan Kim Vijay K. Yadav Gerard Karsenty Young Seok Ju Chan Choi Jae Myoung Suh Jun Yong Park Sangkyu Park Hail Kim
author_sort	Wonsuk Choi
title	Serotonin signals through a gut-liver axis to regulate hepatic steatosis
title_short	Serotonin signals through a gut-liver axis to regulate hepatic steatosis
title_full	Serotonin signals through a gut-liver axis to regulate hepatic steatosis
title_fullStr	Serotonin signals through a gut-liver axis to regulate hepatic steatosis
title_full_unstemmed	Serotonin signals through a gut-liver axis to regulate hepatic steatosis
title_sort	serotonin signals through a gut-liver axis to regulate hepatic steatosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/89d5af7961f4435c8b79cd484b17891a
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Serotonin signals through a gut-liver axis to regulate hepatic steatosis

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