Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling

Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling

Abstract Fibroblast growth factor 23 (FGF23) is a bone-derived endocrine hormone that regulates phosphate and vitamin D metabolism. In models of FGF23 excess, renal deoxyribonuclease 1 (Dnase1) mRNA expression is downregulated. Dnase-1 is an endonuclease which binds monomeric actin. We investigated...

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Autores principales: Daniela Egli-Spichtig, Martin Y. H. Zhang, Alfred Li, Eva Maria Pastor Arroyo, Nati Hernando, Carsten A. Wagner, Wenhan Chang, Farzana Perwad
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/89d7811941be4841a8aed0d4f045fe9c
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