Genome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl

ABSTRACT Taphrina deformans is a fungus responsible for peach leaf curl, an important plant disease. It is phylogenetically assigned to the Taphrinomycotina subphylum, which includes the fission yeast and the mammalian pathogens of the genus Pneumocystis. We describe here the genome of T. deformans...

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Autores principales:	Ousmane H. Cissé, João M. G. C. F. Almeida, Álvaro Fonseca, Ajay Anand Kumar, Jarkko Salojärvi, Kirk Overmyer, Philippe M. Hauser, Marco Pagni
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Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/89d952ab910649569bee1d9210b75cf4
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spelling	oai:doaj.org-article:89d952ab910649569bee1d9210b75cf42021-11-15T15:40:05ZGenome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl10.1128/mBio.00055-132150-7511https://doaj.org/article/89d952ab910649569bee1d9210b75cf42013-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00055-13https://doaj.org/toc/2150-7511ABSTRACT Taphrina deformans is a fungus responsible for peach leaf curl, an important plant disease. It is phylogenetically assigned to the Taphrinomycotina subphylum, which includes the fission yeast and the mammalian pathogens of the genus Pneumocystis. We describe here the genome of T. deformans in the light of its dual plant-saprophytic/plant-parasitic lifestyle. The 13.3-Mb genome contains few identifiable repeated elements (ca. 1.5%) and a relatively high GC content (49.5%). A total of 5,735 protein-coding genes were identified, among which 83% share similarities with other fungi. Adaptation to the plant host seems reflected in the genome, since the genome carries genes involved in plant cell wall degradation (e.g., cellulases and cutinases), secondary metabolism, the hallmark glyoxylate cycle, detoxification, and sterol biosynthesis, as well as genes involved in the biosynthesis of plant hormones. Genes involved in lipid metabolism may play a role in its virulence. Several locus candidates for putative MAT cassettes and sex-related genes akin to those of Schizosaccharomyces pombe were identified. A mating-type-switching mechanism similar to that found in ascomycetous yeasts could be in effect. Taken together, the findings are consistent with the alternate saprophytic and parasitic-pathogenic lifestyles of T. deformans. IMPORTANCE Peach leaf curl is an important plant disease which causes significant losses of fruit production. We report here the genome sequence of the causative agent of the disease, the fungus Taphrina deformans. The genome carries characteristic genes that are important for the plant infection process. These include (i) proteases that allow degradation of the plant tissues; (ii) secondary metabolites which are products favoring interaction of the fungus with the environment, including the host; (iii) hormones that are responsible for the symptom of severely distorted leaves on the host; and (iv) drug detoxification enzymes that confer resistance to fungicides. The availability of the genome allows the design of new drug targets as well as the elaboration of specific management strategies to fight the disease.Ousmane H. CisséJoão M. G. C. F. AlmeidaÁlvaro FonsecaAjay Anand KumarJarkko SalojärviKirk OvermyerPhilippe M. HauserMarco PagniAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 3 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Ousmane H. Cissé João M. G. C. F. Almeida Álvaro Fonseca Ajay Anand Kumar Jarkko Salojärvi Kirk Overmyer Philippe M. Hauser Marco Pagni Genome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl
description	ABSTRACT Taphrina deformans is a fungus responsible for peach leaf curl, an important plant disease. It is phylogenetically assigned to the Taphrinomycotina subphylum, which includes the fission yeast and the mammalian pathogens of the genus Pneumocystis. We describe here the genome of T. deformans in the light of its dual plant-saprophytic/plant-parasitic lifestyle. The 13.3-Mb genome contains few identifiable repeated elements (ca. 1.5%) and a relatively high GC content (49.5%). A total of 5,735 protein-coding genes were identified, among which 83% share similarities with other fungi. Adaptation to the plant host seems reflected in the genome, since the genome carries genes involved in plant cell wall degradation (e.g., cellulases and cutinases), secondary metabolism, the hallmark glyoxylate cycle, detoxification, and sterol biosynthesis, as well as genes involved in the biosynthesis of plant hormones. Genes involved in lipid metabolism may play a role in its virulence. Several locus candidates for putative MAT cassettes and sex-related genes akin to those of Schizosaccharomyces pombe were identified. A mating-type-switching mechanism similar to that found in ascomycetous yeasts could be in effect. Taken together, the findings are consistent with the alternate saprophytic and parasitic-pathogenic lifestyles of T. deformans. IMPORTANCE Peach leaf curl is an important plant disease which causes significant losses of fruit production. We report here the genome sequence of the causative agent of the disease, the fungus Taphrina deformans. The genome carries characteristic genes that are important for the plant infection process. These include (i) proteases that allow degradation of the plant tissues; (ii) secondary metabolites which are products favoring interaction of the fungus with the environment, including the host; (iii) hormones that are responsible for the symptom of severely distorted leaves on the host; and (iv) drug detoxification enzymes that confer resistance to fungicides. The availability of the genome allows the design of new drug targets as well as the elaboration of specific management strategies to fight the disease.
format	article
author	Ousmane H. Cissé João M. G. C. F. Almeida Álvaro Fonseca Ajay Anand Kumar Jarkko Salojärvi Kirk Overmyer Philippe M. Hauser Marco Pagni
author_facet	Ousmane H. Cissé João M. G. C. F. Almeida Álvaro Fonseca Ajay Anand Kumar Jarkko Salojärvi Kirk Overmyer Philippe M. Hauser Marco Pagni
author_sort	Ousmane H. Cissé
title	Genome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl
title_short	Genome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl
title_full	Genome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl
title_fullStr	Genome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl
title_full_unstemmed	Genome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl
title_sort	genome sequencing of the plant pathogen <italic toggle="yes">taphrina deformans</italic>, the causal agent of peach leaf curl
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/89d952ab910649569bee1d9210b75cf4
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Genome Sequencing of the Plant Pathogen <italic toggle="yes">Taphrina deformans</italic>, the Causal Agent of Peach Leaf Curl

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