Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease

T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Tregcell IL-4 production and metabolic alteration to preserve Treg lineage and funct...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Awo Akosua Kesewa Layman, Guoping Deng, Claire E. O’Leary, Samuel Tadros, Rajan M. Thomas, Joseph M. Dybas, Emily K. Moser, Andrew D. Wells, Nicolai M. Doliba, Paula M. Oliver
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89da5cb9551e485e8433cc421115f741
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:89da5cb9551e485e8433cc421115f741
record_format	dspace
spelling	oai:doaj.org-article:89da5cb9551e485e8433cc421115f7412021-12-02T14:42:28ZNdfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease10.1038/ncomms156772041-1723https://doaj.org/article/89da5cb9551e485e8433cc421115f7412017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15677https://doaj.org/toc/2041-1723T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Tregcell IL-4 production and metabolic alteration to preserve Treg lineage and function.Awo Akosua Kesewa LaymanGuoping DengClaire E. O’LearySamuel TadrosRajan M. ThomasJoseph M. DybasEmily K. MoserAndrew D. WellsNicolai M. DolibaPaula M. OliverNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Awo Akosua Kesewa Layman Guoping Deng Claire E. O’Leary Samuel Tadros Rajan M. Thomas Joseph M. Dybas Emily K. Moser Andrew D. Wells Nicolai M. Doliba Paula M. Oliver Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
description	T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Tregcell IL-4 production and metabolic alteration to preserve Treg lineage and function.
format	article
author	Awo Akosua Kesewa Layman Guoping Deng Claire E. O’Leary Samuel Tadros Rajan M. Thomas Joseph M. Dybas Emily K. Moser Andrew D. Wells Nicolai M. Doliba Paula M. Oliver
author_facet	Awo Akosua Kesewa Layman Guoping Deng Claire E. O’Leary Samuel Tadros Rajan M. Thomas Joseph M. Dybas Emily K. Moser Andrew D. Wells Nicolai M. Doliba Paula M. Oliver
author_sort	Awo Akosua Kesewa Layman
title	Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
title_short	Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
title_full	Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
title_fullStr	Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
title_full_unstemmed	Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
title_sort	ndfip1 restricts mtorc1 signalling and glycolysis in regulatory t cells to prevent autoinflammatory disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/89da5cb9551e485e8433cc421115f741
work_keys_str_mv	AT awoakosuakesewalayman ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT guopingdeng ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT claireeoleary ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT samueltadros ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT rajanmthomas ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT josephmdybas ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT emilykmoser ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT andrewdwells ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT nicolaimdoliba ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease AT paulamoliver ndfip1restrictsmtorc1signallingandglycolysisinregulatorytcellstopreventautoinflammatorydisease
_version_	1718389699663364096

Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease

Ejemplares similares