Using both qualitative and quantitative data in parameter identification for systems biology models

Much of the data generated in biology is qualitative, but exploiting such data to inform models of biological systems remains a challenge. Here, the authors demonstrate an approach that allows use of both quantitative and qualitative data for parameterising dynamical models.

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Autores principales: Eshan D. Mitra, Raquel Dias, Richard G. Posner, William S. Hlavacek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/89dae6dda042447f86901a044a4f7f34
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spelling oai:doaj.org-article:89dae6dda042447f86901a044a4f7f342021-12-02T14:39:48ZUsing both qualitative and quantitative data in parameter identification for systems biology models10.1038/s41467-018-06439-z2041-1723https://doaj.org/article/89dae6dda042447f86901a044a4f7f342018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06439-zhttps://doaj.org/toc/2041-1723Much of the data generated in biology is qualitative, but exploiting such data to inform models of biological systems remains a challenge. Here, the authors demonstrate an approach that allows use of both quantitative and qualitative data for parameterising dynamical models.Eshan D. MitraRaquel DiasRichard G. PosnerWilliam S. HlavacekNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Eshan D. Mitra
Raquel Dias
Richard G. Posner
William S. Hlavacek
Using both qualitative and quantitative data in parameter identification for systems biology models
description Much of the data generated in biology is qualitative, but exploiting such data to inform models of biological systems remains a challenge. Here, the authors demonstrate an approach that allows use of both quantitative and qualitative data for parameterising dynamical models.
format article
author Eshan D. Mitra
Raquel Dias
Richard G. Posner
William S. Hlavacek
author_facet Eshan D. Mitra
Raquel Dias
Richard G. Posner
William S. Hlavacek
author_sort Eshan D. Mitra
title Using both qualitative and quantitative data in parameter identification for systems biology models
title_short Using both qualitative and quantitative data in parameter identification for systems biology models
title_full Using both qualitative and quantitative data in parameter identification for systems biology models
title_fullStr Using both qualitative and quantitative data in parameter identification for systems biology models
title_full_unstemmed Using both qualitative and quantitative data in parameter identification for systems biology models
title_sort using both qualitative and quantitative data in parameter identification for systems biology models
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/89dae6dda042447f86901a044a4f7f34
work_keys_str_mv AT eshandmitra usingbothqualitativeandquantitativedatainparameteridentificationforsystemsbiologymodels
AT raqueldias usingbothqualitativeandquantitativedatainparameteridentificationforsystemsbiologymodels
AT richardgposner usingbothqualitativeandquantitativedatainparameteridentificationforsystemsbiologymodels
AT williamshlavacek usingbothqualitativeandquantitativedatainparameteridentificationforsystemsbiologymodels
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